Connective Tissue Flashcards

1
Q

stroma

A

connective tissue that surrounds tissue component of organ

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2
Q

parenchyma

A

functioning part of organ

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3
Q

functions of connective tissue

A
  1. mechanical support and protection of soft tissue
  2. physiological support (molecular exchange)
    a. forms a pathway for blood vessels and nerves
    b. fluids of connective tissues act as a medium of exchange for metabolites between tissues and blood vessels
  3. storage of energy in the form of fat
  4. defense against infection
  5. repair of injuries
  6. maintain boundaries
  7. cell adhesion and movement
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4
Q

components

A

fibres, ground substance, cells

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5
Q

ground substance

A

aqueous, tends to be removed

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6
Q

collagen properties

A

round and squiggly; inelastic; tensile strength; storage of strain energy; abundant

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7
Q

elastic

A

thin; when pulled taut, have sharp angles; can also be squiggly

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8
Q

collagen structure

A

molecule - glycine, proline, hydroxyproline triple helix
fibril - bundle of triple helices
fiber - bundles of fibrils
tissue - tendon, bundles of fibers

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9
Q

types of collagen (and class)

A

type 1 - fibrils, bones, tendons
type 2 - cartilage
type 3 - reticular fibers
type 4 - nonfibrillar (basement membrane)

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10
Q

elastic fibers properties

A
  • strech
  • flexibility
  • branched
  • fenestrated sheets
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11
Q

ground substance component

A
  • glycosaminoglycans (GAGs)

- proteoglycans

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12
Q

ground substance function

A
  • molecular highway/parking lot
  • molecular exchange
  • hydrating molecles
    • more = looser
  • nutrient delivery
  • cell movement (plasma, mast cells)
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13
Q

cells found in connective tissue

A
  • fibroblasts
  • macrophages
  • plasma cells
  • mast cells
  • leukocytes
  • adipocytes
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14
Q

fibroblast function

A

synthesize matrix

wound healing

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15
Q

fibroblast property

A

dense nuclei in connective tissue

large nucleus = active

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16
Q

fibrocyte

A

thin dense nucleus

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17
Q

macrophage

A

called monocyte in blood

v good at endocytosis (particle and dye)

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18
Q

mast cell

A

primary immune response
histamine
large cells - red/purple granules

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19
Q

plasma cell

A
b-lymphocyte in blood
make antibodies (sometimes see golgi bc they're working so hard)
large nucleus (clock face) --> heterochromatin
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20
Q

leukocytes

A
  • neutrophil
  • eosinophil
  • lymphocyte
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21
Q

adipocyte types

A

unilocular, multilocular

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22
Q

unilocular

A

dynamic energy storage

white fat

23
Q

multilocular

A

brown fat - for hibernation - in bears and such

hella mitochondria

24
Q

classifications of connective tissue

A

connective tissue proper, specialised connective tissue, and supporting connective tissue

25
Q

types of connective tissue proper

A

loose (areolar, mucous)

dense - regular (tendon, IEL) or irregular (everywhere)

26
Q

types of specialised connective tissue

A

identification (classification):

reticular (loose), adipose (loose), elastic, hematopoietic, blood

27
Q

what are the supporting connective tissues?

A

cartilage

bone

28
Q

loose connective tissue

A

more nuclei than fibres

pale, pinkish colour

29
Q

areolar connective tissue

A

loose connective tissue
abundant but hard to see - fibres easily visible when ground substance removed
diverse cell population: fibroblasts, lymphocytes, leukocytes

30
Q

mucous connective tissue

A
loose
spare cells (no leukocytes)
more ground substance than fibres
fibroblasts
collagen, no elastin
umbilical cord
31
Q

reticular connective tissue - what type collagen? what class of connective tissue? characterise it. where is it found?

A
reticular fibres
type 3 collagen
specialised connective tissue
loose connective tissue
found in soft cellular tissues (lung/liver/lymphoid)
32
Q

adipose connective tissue

A

each cell has single fat vacuole
white fat
energy storage

33
Q

multilocular

A

each cell has many fat vacuoles
shivering
generate heat

34
Q

dense irregular connective tissue

A
more fibres than ground substance
more fibres than nuclei
mostly collagen
disorganized appearance, no pattern
few cells - most are fibroblasts
dermis of skin
under most epi
resists stress in multiple directions
35
Q

dense regular connective tissue

A

more fibres than ground substance (nuclei)
mostly collagen + elastin
organization repetitiveness
few cells - fibrocytes
tendons, ligaments
resists stress in 1 direction (fibres are oriented)

36
Q

what are the cells in cartilage? what do they rest in?

A

chondrocytes; lacunae

37
Q

what are the two matrices of cartilage? what relative colours do they each stain?

A

territorial - darker

interstitial - lighter

38
Q

ground substance

A

no blood vessels or nerves

passive diffusion of nutrients limits size

39
Q

fibers associated

A

collagen

elastin

40
Q

hyaline cartilage

A

supportive, protective, growth - precursor of bone
spare cells
isogeneous groups are obvious
dense irregular connective tissue

41
Q

characterize hyaline cartilage

A

dense irregular connective tissue

42
Q

identify a type of hyaline cartilage

A

perichondrium

43
Q

elastic cartilage

A

supportive
cells closely packed
isogeneous groups NOT obvious
dense irregular connective tissue

44
Q

characterize elastic cartilage

A

dense irregular connective tissue

45
Q

identify a type of elastic cartilage

A

perichondrium

46
Q

perichondrium

A

consisting of elastic cartilage and hyaline

47
Q

fibrocartilage

A
protective
sparse cells
isogeneous groups in ROWS
red nuclei
dense arrow of collagen fibers
ALWAYS blue stain w red nuclei
48
Q

connective tissue diseases

A
sarcoma
Ehler's-Danlos
Stickler's syndrome
Marfans
scurvy
49
Q

sarcoma

A

occurs in people w AIDS, but rare otherwise

50
Q

Ehler’s-Danlos

A

collagen mutation

51
Q

stickler’s syndrome

A

causes cleft palate mutation

52
Q

marfan’s

A

mutations in fibrillin

53
Q

scurvy

A

issue w collagen formation bc of no vitamin C in the body

bleed to death