Connective Tissue

Question 1

Connective tissue

3

Answer 1

• Originates from mesoderm
• Struct support, medium for exchange
• Defense protect fat storage

Question 2

C.T extracellular matrix

(2 components)

Answer 2

Ground substance

Fibres

Question 3

2 main type of fibres

Answer 3

Collagen, Elastin

Question 4

Collagen features

3

Answer 4

• Structural
• Inelastic
• Triple twisted Tropocollagen alpha molecules

Question 5

Ground substance

Answer 5

Fluid portion w/ glucoaminoglycans, proteoglycan, adhesive glycoproteins

Question 6

4 categories of collagen types

Answer 6

Fibril forming collagen
Fibril assoc. collagen
Network forming collagen
Transmembrane collagen

Question 7

Mesenchyme cells

Answer 7

Mesoderm cells

Multipotent then migrate

Question 8

Fibril forming collagen

3

Answer 8

• Makes fibers for collagen
• Flexible strong fibers, white Tendons, ligaments (Tropocollagen)
• type: I II III V XI

Question 9

Fibril assoc. collagen

3

Answer 9

• Stabilize collagen
• Molecular bridges, collagen to ground substance
• type: XII IX

Question 10

Network forming collagen

3

Answer 10

• Formed by epithelial cells (prod by mesenchyme)
• using procollagen & Tropocollagen to form bridge
• type: IV VII

Question 11

Transmembrane collagen

3

Answer 11

• collagen like protein
• hemidesmosomes
• type: XVII [epidermis to dermis]

Question 12

Elastin fibers

2

Answer 12

• Elastic protein, and surrounded by myofibrils, fibers arranged in parallel bundles (collagen)
• Wavy, can be stretched and relaxed

Question 13

Fixed cells (definition)

Answer 13

Resident population within connective tissue, dont migrate, long lived

Question 14

6 categories of fixed cells

Answer 14

Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient

Question 15

Myofibroblast (definition)

Answer 15

Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament

Question 16

6 categories of fixed cells

Answer 16

Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient

Question 17

Myofibroblast (definition)

Answer 17

Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament

Question 18

6 categories of fixed cells

Answer 18

Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient

Question 19

Myofibroblast (definition)

Answer 19

Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament

Question 20

Pericytes (definition)

Answer 20

Peri-vascular cell,supportive role around blood vessels

Question 21

Adipose cell (definition)

Answer 21

Fat cell have intracellular glob of fat

Question 22

Mast cell

Answer 22

Largest of fixed cells and large cytoplasmic granules (heparin, histamine)

Question 23

Macrophages (definition)

Answer 23

Fixed or transient, remove cellular debris & protect against invators
Dev. from bone bone marrow and move in C.T

Question 24

Kupffer cells

Macrophage

Answer 24

Liver

Question 25

Dust cell (macrophage)

Answer 25

Lungs

Question 26

Langerhans cells (macrophage)

Answer 26

Skin

Question 27

Monocytes (macrophage)

Answer 27

Blood

Question 28

Transient

Answer 28

Migrate from bone marrow to C.T motile, short lived, require specific signal

Question 29

Sarcoma

Answer 29

Cancer on connective tissue

Question 30

Carcinoma

Answer 30

Cancer of epithelial cells

Question 31

Regular fibers

Answer 31

Great tensile strength 1 direction (tendon)

Question 32

Irregular fibers

Answer 32

Tensile strength in multiple ways