Connective Tissue Flashcards
What makes up the ECM (matrix)
Ground substance
Fibers
The most common type of fiber is…
Collagen
The ground substance is made up of ____ and _____
GAGs and PGs
The more sulfates GAGs in the ground substance, the more _____ the tissue
Rigid/robust
What is the diffusion medium of CT?
Ground substance
Besides collagen, what fibers are in the matrix?
Elastin
Amorphous proteoglycans are good at binding _____, especially the sulfated GAGs they exhibit
Water
Collagen types: most common. Present in bone, L-CT, D-CT, Dermis, tendons, capsules of organs
Type 1
Collagen types: collagen of cartilage
Type 2
Collagen types: aka reticular fibers, in dermis, in reticular lamina
Type 3
Collagen types: basal laminar collagen, non-fibrous
Type 4
What is the most abundant protein - 30% of dry body weight?
Collagen
Collagen is mostly secreted by:
Fibroblasts
What type(s) of collagen are fibrillar (make fibers)
Type 1,2,3
What type of collagen forms the basal lamina of the basement membrane
Type 4
Collagen synthesis begins at the _____ where various amino acids (typically lysine and _____) are linked together in a single stranded peptide called _______
rER
Proline
Procollagen alpha chains
In the _____, procollagen alpha chains assemble in a triple helix structure which is then called a _________
rER
Procollagen molecule
Procollagen molecules are soluble and can be stored in ______ until release
Fibroblasts
Procollagen molecules are transferred into the _____ via ______
Golgi apparatus
Transfer vesicles
In the golgi, the Procollagen molecule receives the finishing touches on its inactivation peptides. These peptides will keep the Procollagen molecules from undergoing _______ until they have been secreted
Fibrillogenesis
Procollagen peptidase cleave off the terminal peptides, transforming Procollagen into insoluble collagen molecules, which aggregate to form collagen ______
Fibrils
Procollagen w/o activation peptides
Tropocollagen
Fibrillogenesis: creating fibrils
Fibril—> ______ —> _____
E.g. (many fibrils make a _____ , many of those make a _____)
Fiber
Bundle
What forms covalent bonds between tropocollagen molecules to reinforce the fibril?
Lysyl oxidase