Congenital Fetal Infections

Question 1

Parovirus pathogenesis

Answer 1

Cross placenta, infect red cells progenitors in bone marrows

Question 2

Complications of parovirus

Answer 2

Anemia
Heart failure (attacks fetal cardiomyocytes)
Hydrop fetalis
Death (highest if exposure < 20 weeks)

Question 3

IgG -
IgM -

parovirus

Answer 3

No exposure. But is susceptible. Repeat in 3 weeks because IgM (if she is truly infected) will eventually be detectable.

Question 4

IgG +
IgM -
parovirus

Answer 4

She s immuned! (cuz IgG lasts for years after exposure)

Question 5

igG +/-
IgM +
parovirus

Answer 5

Recent infection!!

Question 6

Adult symptoms of fifth disease

Answer 6

Rash
Fever
Malaise
Joint pain

Question 7

Treatment of severe fetal anemia

Answer 7

Intrauterine blood transfusion

Question 8

Varicella-Zoster Virus

Answer 8

A childhood illness that is benign in children

Devastating if infected as adults (2% of cases)

Question 9

Re-activation of VZV causes:

Answer 9

Herpes zoster (shingles)

Question 10

Fetal complications of VZV

Answer 10

spontaneous abortion
death
growth restriction

Question 11

Neonatal complications of VZV

Answer 11

fever
pneumonia
encephalitis
dermatomal scarring

Question 12

Congenital Rubella Syndrome (CRS)

Answer 12

fetal infection from virus crossing the placenta (infection is chronic and persists after birth).

Question 13

Neonatal complication of CRS

Answer 13

hearing problems
Eye issues
Endocrine

Question 14

ABT for syphilis:

Answer 14

PCN G

For all stages. Treats fetus too by crossing placenta.

Question 15

(following PCN treatment of syphilis)

fever, chill, some hypotension/tachy. Self-limiting (24-36 hrs).

Answer 15

Jarisch-Herxheimer reaction

Question 16

Signs of early congenital syphilis:

Answer 16

Rash
Jaundice
Anemia
Mucous lesions
Snuffles (can be bloody)

Question 17

Signs of late congenital syphilis:

Answer 17

skull bossing
saddle nose
deafness