conformational analysis Flashcards
1
Q
destabilizing factors
A
- steric repulsion due to crowding of big groups
- same charge repulsion
2
Q
stabilizing factors
A
- opposite charge attraction (in gauche)
- h bonding: interaction between h donor and acceptor
- staggered conformation
3
Q
a value
A
how much energy it takes for substituent to be in the axial position of
4
Q
free energy
A
left side - right side
5
Q
gauche interactions
A
- any group that is 60 degrees apart that interacts with each other in a stabilizing or destabilizing way
6
Q
gauche interaction rank
A
- steric hindrance (always destabilizing between two non-h groups)
- charge charge interactions (repulsive or attractive)
- h bonding
