Confguration

Question 1

Enantiomers

Answer 1

Non-superimposable mirror images

Question 2

D/- compounds

Answer 2

Rotate polarised light clockwise

Question 3

L/+ compounds

Answer 3

Rotate polarised light anti-clockwise

Question 4

If a compound has n chiral centres how many stereoisomers does it have

Answer 4

2^n

Question 5

Steric strain

Answer 5

Interpenetration of van der Waal’s forces of substituants

Question 6

Chiral resolving agents for molecules containing basic group

Answer 6

Chiral carboxylic acid which forms diastereomeric salt

Question 7

Chiral resolving agents for neutral molecules with reactive group

Answer 7

Aldehydes/ketones = diols/hydrazones
Alcohols = phthalic anhydrides

Question 8

Chiral resolving agents for carboxylic acids

Answer 8

Chiral base

Question 9

Trans decalins

Answer 9

Structurally rigid and can’t flip

Question 10

Inductive effect

Answer 10

Neighbouring groups/atoms can push/pull electrons in sigma bonds towards/away from them causing a dipole in the C-X bond

Question 11

Mesomeric effect

Answer 11

Donation/withdrawal of electrons via pi-bonds causing polarisation of C-X bond

Question 12

Sn2 only

Answer 12

Methyl and primary alkyl halides

Question 13

Secondary alkyl halides

Answer 13

Sn2 if not too sterically hindered

Question 14

Tertiary alkyl halides

Answer 14

Sn1

Question 15

Burgi-Dunitz trajectory

Answer 15

107 degrees

Question 16

Catalytic hydrogenation of alkenes

Answer 16

H2, Pd/C forms alkanes

Question 17

Antimarkovnikov

Answer 17

Substituent added to least substituted C