Conditions Flashcards
List the possible aetiology of depression
Genetics Early life experience Personality Acute stress Chronic stress Neurobiology (early onset: decrease volume in the hippocampus, late onset: white matter intensely stained on MRI)
What are the main abnormalities observed in depression
- Overactivity of the hypothalamic-pituitary-adrenal axis
- Deficiency of monamines
- Noradrenaline
- Serotonin
- Dopamine
Alternative causes of low mood
Chronic disease: MS, Parkinsons, Spinal cord injury, Cushings, Addisions, Thyroid disorders, Malignancy,Chronic pain, Rheumatoid, Renal failure
Medications: Anti-HTN, Steroids, Oral contraceptives, Levadopa, Opiates
Name the criteria that measure the severity of depression
ICD-10
What are the core and other symptoms of depression
Core:
- Low mood, present everyday for most of the day
- Anhedonia, diminished interest in all things
- Anergia, decrease concentration, decrease self esteem, ideas of guilt and worthlessness, bleak views of the future, ideas/acts of self harm or suicide, disturbed sleep (early waking), decrease appetite, weight loss, reduced libido
Others:
Low mood not secondary to drugs, alcohol, medication, medical disorder
Significant distress or social impairment, struggling to function
Define the levels of depression
MILD: 4+ symptoms (2 core + 2 other)
MODERATE: 5+ symptoms (2 core + 3 others) difficulty in carrying out activities of daily living
SEVERE: 7 symptoms (3 core + 4 others) unable to carry out activities of daily living
List the possible differentials of low mood
Mood disorder (depressive episodes, recurrent illness, dysthymia,bipolar affective diorder)
Schizophrenia (general medical disorder, psychoactive substance use, psychiatric disorder)
Psychotic disorder
Anxiety disorder
Adjustment disorders
Eating disorder
Dementia
Treatment approach to depression
BIOPSYCHOSOCIAL
Pharmacological:
Moderate to severe depression, first line anti depressants or for persistent sub threshold depression
SSRI’S (Sertraline, Paxoteine,Citolopram,Fluoxetine,)
Choose based on potential side effects, safety overdose, previous good results, cannot give TCA in the case of MI/arrthymias
Psychological: First line for mild depression or in conjunction with antidepressant for moderate depression CBT Interpersonal treatment Psychodynamic therapy Family therapy Mindfullness
Social: Avoid alcohol/drugs Eat healthily Exercise repeatedly Good sleep hygenie
Elements of substance dependence
Desire or compulsion to take a substance
Difficulties in controlling a substance
Withdrawal symptoms
Signs of tolerance
Persistent use despite clear harm
time spent seeking, taking recovering from substance over ADL
Safe units of alcohol for male and female
14 units a week
Signs of alcohol dependence
Palpable liver edge Jaundice Spider navi Ascites Palmer erythema peripheral neuropathy ataxic gait
What blood test would you do if you suspected alcohol dependence in a patient and what would you expect to see
LFTS:
- Increase in MCV
- Increase in GGT
- Increase in ALP and ASt
- Carbohydrate deficient transferin
**Urinary ethyl-glucourinde
Treatment of alcohol dependence
BIO Aversive drugs (Disulfiram) inhibits acetalehyde dehydrogenase Increase in acetaldehyde levels Flushings, headaches, nausea and vomiting
800mg reduce to 100-200mg
Anti-craving: Acamprosate (Campral)
thought to work by normalising GABA neurotransmission in the brain
In RCT, patients on acamprosate have increased % remaining abstinent and double
maintanence time
-dose: 666mg td once abstinence is achieved
-indication: those wanting to remain abstinent
-side effects: GI upset, pruritis, rash, altered libido — however, usually well tolerated
PSYCHO
- Motivational interview
- CBT
- Group therapy
- AA
What is the pathology of Wernicke encephalopathy
Spectrum of disease resulting from thiamine deficiency
Haemorrhages and secondary gloss in the periventricular and the periaquaductual grey matter
Involves mammilary bodies, hypothalamus,mediodorsal thalamuc nuclei
Thiamine is the cofactor required by three enzymes in the pathway of carbohydrate metabolism
Signs and symptoms of Wernicke encephalopathy
- Acute confusional state
- Ocular (Ophthalmoplegia (6th nerve palsy), Nystagmus)
- Ataxic gait
- Peripheral neuropathy
- Resting tachycardia
- Nutritional deficiency
Ke investigations for Wernickes encephalopathy
U&Es: exclude hypernatraemia,hypercalcaemia and uraemia. LFTs ABG: rule out hypercapnia and hypoxia Serum thiamine levels Pyruvate (elevated)
Treatment of Wernicke Encephalopathy
Pharmacological:
-IV pabrinex (high potency B1 replacement)
Avoid carb loading until thiamine replacement is complete
Multivitamin to be given indefinately
Non-Pharm: Alcohol abuse management Assess and reassess memory and intellectual impairment OT assessment of daily living Mental capacitiy
Signs and symptoms of Korsakoff’s syndrome
- Acute confusional state
- Ocular (Ophthalmoplegia (6th nerve palsy), Nystagmus)
- Ataxic gait
- Peripheral neuropathy
- Resting tachycardia
- Nutritional deficiency
PLUS CONFABULATIONS
Falsification of memory in clear consciousness
Answer questions promptly with inaccurate and bizarre answers
Impairment to laying down new memories
Variable length of retrograde amnesia
Patient presents in an acute confusional state having recently started alcohol withdrawal
State the diagnosis
Delirium tremens
What are the signs and symptoms of delirium tremens
Severe agitation Confusion Paranoid delusions Hallucinations (visual, auditory and tactile) Clouding of consciousness Disorientation Amnesia of recent events
Malignant hyperthermia Sweating Tachycardia hypertension Tachypnoea Tremor Mydriasis CV collapse
Treatment of delirium tremens
ABCD Hypoglycaemia Sedation Benzodiapenies Parbinex 500mg IV Mg to prevent arrthymias
Explain alcohol dependence syndrome as per the Edwards &Cross Model?
- Narrowing of repertoire
- Increased salience of drinking
- Increased tolerance to alcohol
- Withdrawal of symptoms
- Relief or avoidance of withdrawal symptoms by further drinking
- Subjective awareness of the compulsion to drink
- Rapid reinstatement after abstinence
Medical management of the withdrawal of herion
1) Methadone: Synthetic opioid, longer half life 24 hours. Less in pregnancy
2) Lofexidine: alpha-2-adrenergic receptor agonist, relieves symptoms of withdrawal.
3) Naltrexone: Long acting opiate treatment, helps with the cravings
Explain the triple vulnerability model
1) Genetic: neurobiological ( decreased atomic nervous system response, loss of regulatory cortisol)
2) Generalised psychological vulnerability: childhood trauma/ method of parenting, attachment issues
3) Specific psychological vulnerability: traumatic event
List the risk factors for suicide
Male LGBT Prisioners Single Unemployment Occupation Low socioeconomic status
Psych illness Previous self harm Substance use Family hx of mental conditions Recent adverse life events
Measurements of suicide attempts
Evidence of advanced planing
Precautions taken to avoid discovery
Dangerous/lethal method used
No help sought after the act
List the anecdote for the following overdoses
- Paracetamol
- Morphine
- TCA
N-acetylcysteine
Naloxone
IV sodium bicarbonate
Clinical features of anorexia
General
- Emaciation
- Lanugo hair
- Brittle hair
- Dry skin
- Dental caries
- Fatigue
- Cold intolerance
- Constipation
- Amenorrhea
Cardio
- Prolonged QT
- Arrhythmias
- Low BP
Endocrine/Metabolic
- Low potassium
- High amylase
- Reduced renal function
- Osteoporosis
Diagnostic criteria for anorexia
- Weight <85% less the predicated for height and weight or BMI <17.5
- Intense fear of gaining weight or becoming fat with persistent behaviour to prevent weight gain
- Feeling fat when thin
SCOFF can be used as a screening tool
Red flags for anorexia
- BMI <13
- Wt loss >1kg/week
- T<34.5C
- Vascular Bp 80/50, pulse <40, O2<92%
- Limbs blue and cold
- Proximal muscle weakness
- ECG long QT, flat T waves
- Blood K+ <2.5, Na+ <130
Treatment of anorexia
Psychoeduction about nutrition and weight Nutritional and weight management CBT Family therapy Psychodynamic psychotherapy
Discuss the signs and treatment of refeeding syndrome
Potentially fatal condition due to a fall in phosphate
Signs
- Rhabdomyolysis
- Resp or cardiac failure
- Arrhythmias
- Seizures
- Sudden death
Treatment
- Slow referring according to a careful nutrition plan
- Monitor electrolytes ( potassium, Mg, glucose and phosphate)
Prescribe a thiamine complex
Define bulimia
- Recurrent episodes of binge eating characterised by uncontrolled eating
- Preoccupation with control of body weight
- Regular use of mechanisms to overcome the fattening effect of binges e.g. starvation, vomit induction
- BMI >17.5
Symptoms of bulimia
General
- Fatigue
- Lethargic
- Feeling bloated
- Constipation
- Oesophagitis
- Cardiomyopathy (laxative use)
- Irregular menstruation
- Erosion of dental enamel
- Russells signs ( callouses on the back of the hands due to teeth marks from vomiting)
Metabolic alkalosis Metabolic acidosis ( if using laxatives)
List the ICD-10 criteria for diagnosing bulimia
- Binge eating
- Strong cravings for food
- Methods to counter act weight gain
- Overvalued idea
List the differential dx in a patient presenting with psychosis
- Organic disease
- Delirium
- Delirium tremens
- Metabolic disease - Psychoactive substance abuse
- Cannabis
- Mushrooms
- LSD - Schizophrenia & schizoaffective disorders & delusional disorders
- Affective disorders (depression and mania)
List the 1st rank symptoms which would lead to a diagnosis of schizophrenia
- 3rd person auditory hallucinations
- Passive delusions (figure controlling patients actions)
- Somatic delusions
- Thought insertion, withdrawal and broadcast.
Not 1st rank symptoms Negative symptoms - apathy - blunting of response - social withdrawal - self-neglect - anhedonia - avolition
Explain the pathophysiology of schizophrenia
Dopamine theory
Higher occupancy of dopamine receptors
Increase mesolimbic: +ve symptoms
Increase mesocortical: -ve symptoms
List the types of schizophrenia
Paranoid: paranoid delusion
Often auditory
Per conceptual disturbance
Hebephrenic: Flattening of affect, aviolation, thought is disorganised , speech is incoherent , hallucinations are fleeting and fragment.
Management of schizophrenia
- Antipsychotics
- CBT
- Family intervention
- Art therapy