Conditions Flashcards
Postpartum contraception methods
Lactational amenorrhoea; 98% effective if;
- amenorrhoea
- <6/12 postpartum
- Baby fully breastfed and nil long intervals between feeds (<4hrs day, <6hrs night)
- BUT recommend additional contraception as variable night time feeding and ovulation may still occur
IUD; immediately postpartum
Progestogen-only pill; safe in breastfeeding
COCP; 6/52 postpartum (nil effect on BM from 6/52 onwards)
Ceasing contraception once 50yo
LNG-IUD, POP, implant
- amenorrhoeic for >=12/12
- 2x FSH 6/52 apart - if both >=30IU/L then only need contraception for another 12/12
- OR continue until >=55
Cu-IUD; cease amenorrhoeic 12/12
Contraception + epilepsy
Carbamazepine, phenytoin, lamotrigine -> reduce efficacy of COCP
LVG-IUD, copper IUD, depot are effective
Interacting drugs with contraception (excluding IUD/depot/Copper)
Antiepileptics: carbamazepine, oxcarbazepine, perampanel, phenobarbitone
Antiretrovirals for hiv
Antibiotics: rifampicin, rifabutin
Complementary: St John’s wort
Quick start indications
Irregular/long periods
If unintended pregnancy would cause harm
Difficulties accessing health care
Quick start contraindications
IUD
COCP with cyproterone (feminisation of foetus)
How to exclude pregnancy
Negative preg test + nil UPSI in last 3/52
Nil intercourse since period
Consistent with current contraception
within 5 days of start of period
21 days postpartum
5 days post abortion/miscarriage
COCP UMEK
Smoking
- >=35yo + >=15cig = 4
Obesity
- BMI >=35 = 3
HTN
- >=160/100 = 4
Vascular disease = 4
Previous CVA/IHD = 4
Hx VTE = 4
Fhx VTE = 3
Migraine + aura = 4
Current breast Ca = 4
Contraindications IUD
PID
STD
Unexplained PV bleeding
Cervical/endometrial Ca
LNG-IUD
52mg (menorrhagia/dysmenorrhoea/endo) or 19.5mg (dysmenorrhoea, reduce bleeding)
Contra; breast Ca, PID
Copper IUD
Immediately effective at any time
Complication; expulsion, PID, ectopic, perforation
Avoid sex 48hrs post insertion
Implanon
etonorgestrel 68mg every 3 years
Contra; breast Ca
Advantage
- cost-effective
- can quick start
- safe postpartum + breast feeding
- Amenorrhoea in 22%
- Improves dysmenorrhoea
Risks; infection, scarring, cysts
Mx bleeding on implanon
1st line; COCP continuously 3/12, mefenamic acid 500mg TDS 5/7, TXA 500mg BD 5/7
2nd line; norethisterone 5mg TDS 21/7
Depot medroxyprogesterone
Medroxyprogesterone 150mgcg 12/52ly
Consider; contraindication to COCP, drugs that induce liver enzymes, wanting discrete method
Risks; CVD risk, BMD
Contra; breast Ca
Precaution; IHD/CVA/TIA, CVD risk factors, avoid >50yo
Disadvantage; altered bleeding, low continuation rate, 20% have weight gain, loss of bone density, 18mo return of fertility
Late depo injection
up to 14/52 since injection is ok
14/52 + 1 or more days
- if UPSI within last 5/7 - need emergency contraception
- multiple UPSI >5 days ago and <=3/52 ago -> urine test needed
POP
Consider if oestrogen contraindication
Quick start = immediately effective - otherwise takes 3 pills before being effective
Contra; breast Ca
Precaution; unexplained PV bleed, Hx breast Ca, cirrhosis/liver disease, IHD/CVA/TIA that develops during use
Disadvantage; 3hr window, altered bleeding, low continuation rate, ectopic pregnancy,
Missed POP
1 pill missed
- immediately take, condoms until 3 consec pills
- consider EC if UPSI occurred in time since missed pill
>1 pill missed
- take most recent missed pill and condoms for 3 consec pills
- consider EC if UPSI occurred in time since missed pill
Oestrogen types in COCP
Estradiol
Ethyinylestradiol
Mestranol
Progestogen types in COCP
1st gen; norethindrone
2nd gen; levonorgestral, norethisterone
3rd gen (less androgen, more VTE)
- desogestral, etonogestrel
Unclassified; cyproterone acetate, drosperinone
- both antiandrogenic
COCP advantages
Tx
- acne
- menorrhagia
- dysmenorrhoea
- endometriosis
- PCOS
- PMS
Reduce risk
- endometrial/ovarian/bowel Ca
COCP disadvantages
high user involvement
VTE risk
MI/CVA risk
increase risk cervical/breast Ca
HTN
irregular bleeding
COCP contraindications
Breastfeeding <6/52 postpartum
Smoker >35 and >15 cig per day
Migraine + aura
HTN >160/110
>50yo
Hx VTE
Breast Ca
Cirrhosis/liver ca
Known thrombogenic mutations
Mx COCP ADR
Breakthrough bleeding
- Higher dose oestrogen or less androgenic progestin
- extending cycling
Breasts tenderness
- reduce oestrogen/progestogen dose
Nausea; take at night
Headache; reduce oestrogen
Bloating; reduce oestrogen or change to diuretic progestogen (drosperinone)
COCP missed
> 24hrs overdue
- take most recent
- condoms 7/7
- if <7 pills from placebo -> EC if UPSI in last 5/7
- <7 till next placebo - skip and take active
COCP types
Microgynon ED; ethinyloestradiol 20mcg + levonorgestral 100mcg
Levlen ED; ethinyloestradiol 30mcg + levonorgestrel 150mcg
Microgynon 50; ethinyloestradiol 50mcg +levonorgestral 125mcg
Brenda-35; ethinyloestradiol 35mcg + cyproterone 2mg
Yaz; ethinyloestradiol 20mcg + drosperinone 3mg
Yasmin; ethinyloestradiol 30mcg + drosperinone 3mg
Ulipristal acetate
30mg dose
Best taken within 24hrs - but can use up to 5 days UPSI
Contra; severe asthma, severe liver impairment
If vomiting within 3hrs ingestion - repeat dose
Delay resumption of contraception until 5 days after dose
Levonorgestrel EC
1.5mg PO within 72hrs
if vomit <2hrs - repeat
if on liver enzyme-inducing drug - take 3mg
Avoid in obese due to risk of failure
Resume contraception immediately within LNG-ECG
Minipill as EC
25x minipill 12 hrs apart (50 tab)
Copper IUD EC
Within 5 days UPSI
Good option if taking liver enzyme inducers, BMI >30
Can keep in for ongoing contraception
Need to screen for STI in high risk
Need preg test 3/52 post UPSI
Copper IUD EC
Within 5 days UPSI
Good option if taking liver enzyme inducers, BMI >30
Can keep in for ongoing contraception
Need to screen for STI in high risk
Need preg test 3/52 post UPSI
Signs of secondary dysmenorrhoea
Onset in third decade of life or later
Dyspareunia
Heavy menstrual bleeding
Intermenstrual bleeding
Post-coital bleeding
Irregular periods
Poor response to 3/12 tx
Signs of endometriosis/fhx of same
Mx dysmenorrhoea
1st line; NSAID or COCP
Ibuprofen 400mg TDS for 72hrs of menstruation
Mefenamic acid 500mg TDS for 72hrs of menstruation
Local heat
Acupuncture
Diet; thiamine, magnesium, fish oil
Secondary dysmenorrhoea causes
Endometriosis
Pelvic infection
Adenomyosis
Fibroids
Chronic PID
Ovarian cysts
Cervical stenosis
Abnormal uterine bleeding causes
PALM COEIN
Polyps
Adenomyosis
Leiomyoma
Malignancy
Coagulopathy
Ovulatory dysfunction
Endometrial
Iatrogenic
Not classified
Primary amenorrhoea
Failure menses by age 16yo with normal secondary sex characteristics
Causes
- Hypothyroidism
- HPRL
- PCOS
- Androgen insensitivity
- Mullerian agenesis
- Turner’s
- Low FSH; constitutional delay, pituitary failure, T1DM
Secondary amenorrhoea
amenorrhoea for 6/12
Causes
- Pregnancy
- Functional hypothalamic amenorrhoea (weight change, stress, eating disorder)
PCOS
Prolactinoma
Premature ovarian failure
Thyroid disease
Exogenous androgen use
Cervical stenosis
Asherman’s syndrome
Sheehan syndrome
Congenital adrenal hyperplasia
Secondary amenorrhoea Ix
bHCG
FSH/LH
Oestradiol/testosterone
TSH
PRL
Pelvic USS
Premature ovarian insufficiency
<=40yo with irregular periods or amenorrhoea >=4/12
FSH >=25 on 2x occasions 6/52 apart confirms Dx
Consider karyotyping - Fragile X or Turner syndrome
Autoimmune screen with (ANA) - could be autoimmune POI
Consequences
- Menopause
- Accelerated cognitive impairment
- CVD
- Inferility
- Osteoporosis
- Premature mortality
Asherman’s syndrome
Adhesions inside uterus +/- endocervix
Sx
- light period, amenorrhoea, infertility, miscarriage
Risk; curettage post miscarriage
DUB
Heavy/prolonged/frequent bleeding of unknown cause
Tx
- Cease smoking
- Dietary iron
- Exercise
- Tranexamic acid
- Naproxen / mefenamic acid
- COCP
- Oral progesterone
- Depot
- IUD