Conditions Flashcards
What classifications of bipolar are there?
Bipolar I – 1 or > manic episodes or mixed episodes, +/- 1 or > depressive episodes
Bipolar II – 1 or > depressive episodes with at least 1 hypomanic episode
Bipolar - Repeated episodes of hypomania or mania only are classified as bipolar.
Bipolar Affective Disorder ICD 10
Disorder characterized by two or more episodes in which the patient’s mood and activity levels are significantly disturbed, this disturbance consisting on some occasions of an elevation of mood and increased energy and activity (hypomania or mania) and on others of a lowering of mood and decreased energy and activity (depression).
Requires at least 2 episodes, one of which must be a hypomanic, manic or mixed episode
What are some of the causes of mood disorders?
- Biological – Genetic (more in bipolar disorder), Brain illnesses, Physical Illnesses (e.g. hyperthyroidism)
- Psychological - Childhood experiences (e.g. suffering abuse), view of yourself and the world, personality traits (e.g. obsessive and dependent)
- Social - work, housing, finance, relationships, support etc.
How is bipolar affective disorder managed?
- Hypo/ mania: consider stopping antidepressant if the patient takes one; antipsychotic therapy e.g. olanzapine or haloperidol
- Prophylaxis: mood stabilizer: lithium carbonate (if compliance is good, UE, ECG and T4 normal) – also teratogenic. 2nd: valproate
- Check lithium levels weekly (12h post first dose) until the dose has been constant for 4 weeks, then monthly for 6 months then 3 monthly
- Diuretics, NSAIDS, Acei all increase lithium
- Avoid changing lithium brands
- Mx of depression: talking therapies (see above); fluoxetine is the antidepressant of choice
What is mixed affective state?
This is characterised by either a mixture or a rapid alternation (usually within few hours) of hypomanic, manic and depressive symptoms
What are the symptoms of mania?
- Mood: Elevated (for at least 1 week) / expansive/ irritable/ euphoria
- Cognition: grandiosity/ increased self esteem, distractibility/ poor concentration, flight of ideas/ racing thoughts, confusion, lack of insight
- Behaviour: rapid speech, hyperactivity, reduced sleep, hypersexuality, extravagance, Social inhibitions lost e.g. dangerous activities. Impaired judgement
- Psychotic symptoms: delusions and hallucinations
- Speech: increased pressure of speech
What are the symptoms of hypomania?
Symptoms of Hypomania – symptoms of mania but not psychotic symptoms – decreased/ increased function for 4 days or more
Several of the following features with considerable interference with work/social activity for at least several days
- Mildly elevated, expansive or irritable mood
- Increased energy/activity
- Increased self esteem
- Sociability, talkativeness, over familiarity
- Increased sex drive
- Reduced need for sleep
- Difficulty in focussing on one task alone
What are some of the causes of mania?
- Medication: steroids, illicit substances (amphetamines, cocaine, anti depressants)
- Physical: infection, stroke, neoplasm, epilepsy, MS, metabolic disturbance (hyperthyroidism)
What are the core symptoms of depression?
- Continuous low mood for at least 2 weeks
- Lack of energy (fatigue)
- Lack of enjoyment/ interest; (anhedonia) – inability to enjoy any activity
What are some of the biological symptoms of depression?
- Sleep changes – EMW – hypo (older adults) or hypersomnia (more common with adults)
- Appetite and weight changes – gain (atypical depression) and loss of weight (more common)
- Diurnal variation of mood – worse in morning, better by evening
- Psychomotor retardation/ agitation – not wanting to move much, prefer to stay in one place
- Loss of libido
What are some of the cognitive symptoms of depression?
- LOW SELF ESTEEM – negative view of yourself and the future
- GUILT/SELF BLAME – can continue for a very long time. Can make us multiply bad feelings.
- HOPELESNESS
- HYPOCHONDRICAL THOUGHTS
- POOR CONCENTRATION/ATTENTION – ie difficult to study and get on with things. Unable to remember. Pseudodementia – depression impairing cognitive ability
- SUICIDAL THOUGHTS
What is the diagnostic criteria of mild, moderate and severe depression?
- Mild – 2 core + 2 others (able to function!) – functionality is important. Get them back to what they were doing before
- Moderate – 2 core + 3 (or 4) others
- Severe – 3 core + at least 4 others
- Severe with psychotic symptoms
How is depression managed?
- Mild: computerized CBT, self help, mindfulness, sleep hygiene, problem solving techniques. Only use SSRI is sx persist beyond 8 weeks
- Moderate: anti depressant and high intensity psychological intervention (8-12 sessions CBT), IAPT
- Severe depression: Includes psychotic depression. High risk of suicide. Needs rapid specialist mental health assessment, inpatient admission (using MHA if necessary), ECT
What is psychotic depression made up of?
- Hallucinations (often auditory) – can be in all 5 senses
- Delusions - Hypochondriacal/ Guilt/ Nihilistic/ Persecutory
What is post natal depression and what are some RFs?
- 10 – 15% of women usually within 1-2 months post partum but can appear later in some women
- Thought content may include worries about the baby’s health or her ability to cope adequately with the baby
- Risk factors – personal or family history of depression, older age, single mother, unwanted pregnancy, poor social support, previous PND
What is the prognosis of bipolar disease?
- Poor prognosis suggested by :- severe episodes, early onset, cognitive deficits
- Treatment is more effective earlier in the course of illness
- 80% relapse after first episode within 5-7 years