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Immunology And Serology > Comprehensive Review > Flashcards

Comprehensive Review Flashcards

Review for pre boards

1
Q

Primary goal of immunolgy

A

Immunity

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2
Q

Discovered cellular theory of immunity

A

Metchnikoff 1883 to 1905

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3
Q

Prevents entry and establishment of pathogen in the body

A

External defence system

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4
Q

Bridges innate and adaptive immunity

Largest lymphocyte

A

Nk cells

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5
Q

Multicolony stimulating factor

A

IL 3

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6
Q

Alpha 1 antirtrypsin deficiency

A

Premature emphysema/liver dse

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7
Q

Most potent opsonin

A

CRP

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8
Q

Location of MHC

A

Chromosome 6p

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9
Q

Most potent APC

A

Dendritic cells

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10
Q

Massive overproduction of cytokine leading to shock , multi organ failure

A

Cytokine storm

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11
Q

Rearrangement of genes coding for heavy and light chains of antibody

A

Pro b cells

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12
Q

Synthesis of heavy chain

A

Pre B cell

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13
Q

Immunohlobulin present in mature B cells

A

Surface IgD and IgM

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14
Q

Most efficient in fixing complement

A

IgG3

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15
Q

who developed the side chain theory of anti-body?

A

Ehrlich

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16
Q

steps in PCR

A

Denaturation- heat at 95
annealing-cool to 52
Elongation-72

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17
Q

at which stage of syphilis does hard chancre be seen

A

Primary

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18
Q

confirmatory test of HIV in the Philippines

A

RHIVDA

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19
Q

what are the bands present in the confirmatory test of HIV

A

p24, GP 120/160, gp41

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20
Q

screening test for HIV

A

ELISA

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21
Q

A marker of hepatitis that shows immunity

A

Anti-HBs

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22
Q

A marker of hepatitis that shows recovery

A

Anti-HBe

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23
Q

A lifelong marker of hepatitis

A

IgG Anti-HBc

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24
Q

A marker of hepatitis that shows current or recent infection “Core Window Period”

A

IgM Anti-HBc

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25
Q

A marker of hepatitis that shows a high degree of infectivity

A

HBeAg

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26
Q

A marker of hepatitis that shows active infection

A

HBsAg

27
Q

The most specific cells containing antigens that agglutinate with heterophile antibodies

A

Sheep erythrocytes

28
Q

Serologic test that differentiates Heterophile anti-bodies associated with infectious mononucleosis, serum sickness or Forssman Ag

A

Davidsohn differential test

29
Q

Largest cell in the peripheral Blood

A

Monocyte

30
Q

MHC CLASS 1

A

All nucleated cells
CD8
Endogenous Ag
structure 3 alpha; 1 beta

31
Q

Antigen in MHC CLASS 3

A

Benett Goodspeed

32
Q

Gold standard for identification of lymphocyte

A

Flow Cytometry

33
Q

Enzyme Digestion that cleaves an antibody molecule into 3 pieces = 2 Fab; 1 Fc

A

Papain; Rodney Porter

34
Q

Enzyme Digestion that cleaves an antibody molecule into 2 pieces = 1 Fab; 1 Fc

A

Pepsin; Alfred Nisonoff

35
Q

Variable Regions of immunoglobulins are found in what End of each chain

A

Amino-terminal End

36
Q

Constant region of immunoglobulins are found in what end of each chain

A

Carboxyl-terminal end

37
Q

a compound that enhances immune response, it is not immunogenic and cannot induce an antibody response

A

Adjuvant

38
Q

Formerly used as potentiator before PEG

A

Sendai Virus

39
Q

Medium for Hybridoma technique

A

Hypoxanthine-Aminopterine-Thymidine

40
Q

The structure formed by the fusion of engulfed materials and enzymatic granules within a phagocytic cell is called a

A

Phagolysosome

41
Q

IgM

A

Fixes Complement
Has a J Chain
Primary response antibody

42
Q

Bence Jones Protein is identical to

A

L chains

43
Q

soluble antibody combines with soluble antigen

A

Precipitation

44
Q

Antibody + particulate antigen

A

Agglutination

45
Q

unit of sedimentation rate of imunoglobulins

A

Svedberg

46
Q

antigens capable of inducing immune response

A

immunogens

47
Q

Complement system is inactivated at

A

56-degree celsius for 30 mins- use within 4 hours

48
Q

complement deficiency that has no known associated dse

A

C9

49
Q

most common complement deficiency

A

C2

50
Q

Most severecomplement deficiency

A

C3

51
Q

preferred method of screening type 1 (hypersensitivty reacton)

A

in vivo prick test

52
Q

Most immunogenic

A

Bone Marrow

53
Q

Least immunogenic

A

Cornea

54
Q

plays an important role as an external defense mechanism?

A

Phagocytosis

55
Q

Flagellar antigens are designated

A

H antigen

56
Q

A graft from a mother to her child would be a/an

A

Allograft

57
Q

A negative test for VDRL but positive for FTA-ABS correlate with

A

Early syphillis

58
Q

Serologic diagnosis for cryptococcus can be made by testing what specimen/s?

A

CSF

59
Q

In agglutination, if cells are not centrifuged long enough the results would be

A

False Negative

60
Q

exact binding type of an antigen

A

Epitope

61
Q

complement deficiency associated with Hereditary Angiodema

A

C1INH

62
Q

it measures the total serum IgE

A

Radioimmunosorbent test (RIST)

63
Q

it measures antigen specific IgE

A

Radioallergosorbent test (RAST)

Immunology And Serology (1 decks)

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