Comprehensive Finals Flashcards
DNA is double helix held together by _______
base pairs
base pairs are held together by ____________
hydrogen bonds
cytosine -
guanine
adenine -
thymine
- process used by the cell to make identical copies of DNA
Replication
- contain the genetic code
nucleic acids
- nucleotides which are building blocks
monomers
RNA bases:
Adenine
Uracil
Cytosine
Guanine
The order of the ______ determine the genetic code
base pairs
_____ are a group of 3 nucleotides which code for amino acids
codons
- appearance
phenotype
- genetic constitution or composition
genotype
- a genetic structure in a cell that can replicate independently of the chromosomes, often in bacterium or protozoans
plasmid
- any agent that causes a disease
Pathogen
Types of pathogens:
- virus
- bacterium
- protozoan
- fungus
- helminth
- scientific study of disease
pathology
- scientific study of the cause of disease
Etiology
- the microbial cause of disease (pathogen)
Etiological agent
- colonization of the body by pathogens
infection
- disruption of bodily functions
disease
microorganisms that permanently colonize the body are called _________
normal flora
the _____ has the most bacteria
mouth
_____ is used to determine the age of a disease
Koch’s postulate
Koch’s postulate
- the microorganism or other pathogen must be present in all cases of the disease
- the pathogen can be isolated from the diseased host and grown in pure culture
- the pathogen from the pure culture must cause the disease when inoculated into a healthy, susceptible laboratory animal
- the pathogen must be reisolated from the new host and shown to be the same as the originally inoculated pathogen
- objective and measured by a physician
Sign
- subjective and apparent to a patient
symptom
- local outbreak
Epidemic
- carriers a pathogen (human, animal or fomites)
Reservoirs
- worldwide outbreak
Pandemic
- the science that deals with when and where a disease occurs
Epidemiology
- ability to cause disease
Pathogenicity
- severity of a disease
Virulence
A _____ helps to penetrate a hosts’ defense
capsule
_____ of the cell wall resists phagocytosis, heat, and acids
M-Protein
____ speed up chemical reactions and end with (ase)
Enzymes
- death of a tissue
Necrosis
____ are poisons produced by microbes
Toxins
____ are secreted outside of a microbe
Exotoxins
Lysis can release exotoxins and induce a _____
fever
_______ symptoms include thrush and yeast infections
Candida albicans
Conjunctiva (eye) species:
Corynebacterium species
Haemophilus species
_____ - factors inherent in the body. Provides a defense against infection
natural resistance
___________ - provides a mechanical and chemical barrier
skin and mucous membranes
_______ - antiviral substance
Interferon
Phagocytosis - leukocytes that destroy _____ substances
foreign
_______ - responce to injury
inflammation
Hallmark of inflammation ______, ________, _______-, and _______-
Dilation, Erythema (reddening), Edema(swelling)/pyogenesis(pus formation), and Fever
__ - circulating antibody, only immunoglobulin to cross the placenta
IgG
__- First antibody produced during antibody reaction
IgM
__ - anti body to invade microorganisms (breast milk)
IgA
__ - involved in hypersensitivity reactions
IgE
__ - On the surface of lymphocytes, important in B-cell activation
IgD
________ - term used to describe serum proteins that help antibodies destroy forgiven particles
complement
________ antimicrobial drugs - act upon a large number of G+ and G-
broad spectrum
______ - drugs made by bacterium or fungi
antibiotics
antimicrobial drugs act ______ a host
within
_________ vaccine - uses harmless antibodies to stimulate antigen
anti-idiotypic