Compounding Prep + Procedures Flashcards

1
Q

Communition

A

reduction of particle size

3 methods:
1. Trituration = mixing with mortar and pestile
2. Levigation = grinding with liquid creating a paste
3. Pulverization = used for HARD solids like crystalline

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2
Q

Sieves

A

“sifters”
ensure particle size is uniform

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3
Q

Geometric Dilution

A

small amount of drug, add an equal amount of diluent, keep doubling the amount untill it is evenly mixed

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4
Q

Solution

A

Solute fully dissolved in a solvent

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5
Q

Suspension

A

a solid dispersed throughout a liquid
**needs a levigating agent (type of surfactant) for wetting the solid before incorpation into liquid

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6
Q

Emulsion

A

a liquid dispersed into liquid (water in oil or oil in water)
**need emulsifier (type of surfacant)

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7
Q

Suppository Preparation

A

Need to calulcate density factor to assess how much of the drug will be displaced

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8
Q

BUD for nonaqueous formulation

A

6 months
store at room temp

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9
Q

BUD for aqueous oral formulation

A

14 days
store in fridge

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10
Q

BUD for aqueous topical/dermal
(cream/lotion)

A

30 days
store at room temp

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11
Q

How many days should a max BUD for a product that has diclofenac powder in propylene glycol?

A

180 days (6 months)

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12
Q

What is the max BUD for a topical zinc oxide in white petrolatium?

A

6 months (180 days)

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13
Q

What is the max BUD for Cipro in Versabase lotion?

A

30 days

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14
Q

How long can you store a nystatin popsicle in 80% sorbitol and water?

A

14 day in the fridge

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15
Q

unit dose repackaging expiration date

A

6 months (180 days)

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16
Q

Small Volume Parenteral

A

< or = 100 mL

17
Q

Large volume parenteral

A

> 100 mL

18
Q

Low risk sterile compounding

A

1 - 3 components supplied as “sterile

19
Q

Medium risk sterile compounding

A

> 3 componetns supplied as “sterile”

20
Q

High risk sterile compounding

A

When you must sterilize the formulation AFTER it has been compounded — not common

21
Q

With high risk CSP what is the room temp, fridge and freezer BUD?

A

Room temp BUD = 24 hours
Fridge = 3 days
Freezer = 45 days

22
Q

With medium risk CSP what is the room temp, fridge, and freezer BUD

A

Room temp BUD = 30 hours
Fridger = 9 days
Freezer = 45 days

23
Q

With low risk CSP what is the room temp, fridge, and freezer BUD?

A

Room temp = 48 hours
Fridge = 14 days
Freezer = 45 days

24
Q

BUD for single dose container of a bag or vial when it outside the ISO 5 environment?

A

1 hour from puncture

25
Q

BUD for single dose container of a bag or vial when it inside the ISO 5 environment?

A

6 hours from time of puncture

26
Q

BUD for multi dose container when its inside or outside the ISO 5 environment?

A

up to 28 days from puncture

27
Q

Recalls by class

A

Class I = reasonable probability of serious ADR or death
Class II = causing temporary or reversible health consequences
Class III = unlikely to cause any harm