Complications of Labor Flashcards
Definition of preterm labor?
Regular uterine contractions occurring at least q10min resulting in cervical change prior to 37 weeks.
What is the weight threshhold for Low Birth Weight (LBW)?
Very Low Birth Weight (VLBW)?
<2500g=LBW
<1500g=VLBW
Between what two weeks gestation does survival rate increase by 5% each day?
Between 25-26 weeks.
There is an association with preterm labor and what 3 genital tract colonizations?
- Group B Strep
- Neisseria gonorrhoeae
- Bacterial Vaginosis organisms
What can be done to stop or attempt to slow contractions to avoid Preterm labor?
Tocolytic therapy (also an epidural can avoid pushing).
Tocolytic therapy can be used up to how many weeks gestation?
34 wks
What is the ultimate goal of tocolytic therapy?
Short term use to permit corticosteroid treatment to aid fetal lung maturation and allow potential transfer to NICU prepared facility.
What are the 6 tocolytic therapies available?
- Ethanol
- Magnesium
- Calcium-Channel Blockers
- Beta-Adrenergic Agonists
- Prostaglandin Synthetase Inhibitors
- Methylxanthines
How does methylxanthines (aminophylline) produce tocolysis?
Phosphodiesterase inhibitor which increases cAMP, causes uterine muscle relaxation.
What is an example of a Calcium Channel Blocker used in tocolytic therapy?
Nifedipine
What are maternal side effects of Nifedipine use?
- Hypotension, tachy, dizzy, palpitations, flushing
- Myocardial depression
- Hepatic dysfunction
- Postpartum hemorrhage
- Decrease UBF=fetal hypoxemia
Why do calcium channel blockers increase risk of post-partum hemorrhage?
Uterine atony refractory to oxytocin and prostaglandin F-a2
What are two examples of Prostaglandin Synthetase Inhibitors?
- Indomethacin
2. Sulindac
MOA of indomethacin and sulindac?
Decrease cyclooxygenase which decreaes prostaglandins
What are maternal side effects of indomethacin and sulindac?
- Nausea
- Heartburn
- Transient dec. bleeding aggregation (bleeding)
- Primary Pulm HTN
What are fetal side effects of indomethacin and sulindac?
- Crosses placenta
- Premature closure of ductus arteriosus
- Persistent fetal circulation
- Renal impairment- oliguria.