Complications of Labor Flashcards
Complications include:
-prematurity/ preterm labor
-multiple gestation
-uterine rupture
-abnormal presentation
-postmaturity
-intrauterine fetal death
Mean duration of pregnancy is ________ wks from first day of LMP
40 weeks
How many weeks is considered a “term pregnancy”?
37- 42 wks.
What is considered preterm labor?
Regular uterine contractions occurring at least 10 mins apart resulting in cervical change any time before 37 weeks.
What is considered low birth weight (LBW)?
< 2500 g at birth
What is considered very low birth weight (VLBW)?
< 1500 g
At how many weeks are >90% of fetus’ <1500 g
29 weeks
Mortality is 90% of infants born before _____weeks
24 weeks
Survival exceeds 90% for babies born more than _____ weeks
30 weeks
Survival is more than 98% for babies born by ____ weeks
34 weeks
Survival can increase by ______% each DAY between ____ and ____ weeks
5% between 25-26 weeks
What is respiratory distress syndrome exacerbated by?
Intrapartum hypoxia and maternal stress
- Almost all infants <27 weeks
almost none have respiratory distress by 36 weeks.
What are some prematurity comorbidities?
-Respiratory distress syndrome
-Sepsis
-Necrotizing enterocolitis
-Intracranial hemorrhage (uncontrolled delivery/trauma, neonatal HTN)
- ischemic cerebral damage
-immature metabolism (prolonged drug effects)
-HYPOGLYCEMIA
-HYPOTHERMIA
-Hyperbilirubinemia
What might cause preterm labor?
Preterm labor :with genital tract colonization w/: –
-Group B strep
-Neisseria gonorrhoeae
-Bacterial vaginosis
(some success at preventing preterm labor w antibiotic tx, no current recommendations for routine screening for asymptomatic infections
What does tocolytic therapy do?
Attempt to stop or slow contractions to avoid Preterm Labor.
When would tocolytics be used?
-gestational age: 20-34 wks.
-EFW < 2500g
-Absence of fetal stress
-Used for short term (<48 hrs) to permit corticosteroid treatment to aid fetal lung maturation, or allow transfer to facility w appropriate NICU facilites
Ethanol: no longer used d/t side effects
-Inhibits release of antidiuretic hormone and oxytocin.
-Possible direct effect on myometrium or interference with prostaglandins.
-IV bolus and maintenance infusion over total of 12 hr.
-Significant risk of intoxication, loss of consciousness and aspiration.
-No longer used d/t side effects and superior drug availability.
Methylxantheines
- Aminophylline
-Phosphodiesterase= increase intracellular cAMP= uterine muscle relaxation
- Narrow therapeutic margin and frequent toxic side effects limit clinical use
Calcium channel blockers
-Nifedipine
- Myometrium contractility related to free calcium concentration
- decreased ca2+ = decreased contractility
Maternal side effects of calcium channel blockers
-HoTN
-Tachycardia, dizziness, palpitations
-facial flushing
-vasodilation
-peripheral edema
-myocardial depression
-conduction defects
-hepatic dysfunction
-postpartum hemorrhage- d/t uterine atony refractory to oxytocin and prostaglandin F alpha2
-fetal side effects
-decreased UBF= fetal hypoxemia and fetal acidosis
- Pt may be more prone to cardiac depressant effects of volatile agents
Prostaglandin Synthetase inhibitors : Indomethacin, Sulindac
MOA: decrease cyclooygenase= decrease prostaglandin
Maternal side effects:
- Nausea
- Heatburn
-transient decrease in platlete aggregation = bleeding
- primary pulm HTN
Fetal side effects:
-crosses placenta
-premature closure of ductus arteriousus
-persistant fetal circulation
-renal impairment, transient oliguira
Magnesium
- May compete w calcium for uterine smooth muscle surface binding= decreased contractility
-prevents an increase in intracellular calcium
-Activates adenylcyclase= increased cAMP
Pts more sensitive to depolarizing and non-depolarizing muscle blockers
- MAC IS DECREASED
- renal elimination
-dose: 4-7mg/100mL
What happens with a serum mag values of 8-10
loss of deep tendon reflexes
What happens with a serum mag value of 10-15?
respiratory depression
cardiac conduction defect (Wide QRS, increased PR interval)
What happens w a serum mag value of 20+
CARDIAC ARREST
What is the treatment for magnesium toxicity?
Calcium gluconate or CaCl
What drugs are beta-adrenergic agonists?
Terbutaline, Ritodrine
MOA: direct stimulation of B-adrenergic receptors in uterine smooth muscle = increased cAMP= uterine relaxation
Side effects:
-N/V
- anxiety
-restlessness
-Hyperglycemia
-hyperinsulinemia
-HYPOkalemia
-acidosis
-tachycardia, arrhythmias, peripheral vascular resistance, dilutional anemia
-decreased colloid oncotic pressure
-pulmonary edema
What are the risk factors for beta-agonist pulmonary edema
Increased IVF administration
multiple gestations
tocolysis greater than 24 hrs.
concomitant mag therapy
infection (Increase pulm cap permeability)
hypokalemia
undiagnosed heart disease
Why is the mortality of the second twin greater than the first?
-placental abruption
-cord prolapse
-malpresentation
Maternal consequences of multiple gestation
Cardiovascular:
-Increased cardiac output earlier in gestation
Hematologic:
-Increased incidence of anemia
Respiratory:
-Dec. TLC, dec. FRC, inc. closing capacity
Metabolic:
-Inc. oxygen consumption, inc. metabolic rate
Reproductive:
-Larger uterus – aortocaval compression, greater aspiration risk
What complications increase with multiple gestation?
Increased risk of pregnancy induced hypertension
placental abruption
placenta previa
malpresentation
increased risk of hemorrhage
What is the preferred local used for neuraxial block for multiples?
2-chloroprocaine 3% preferred for rapid onset
1.5% lido w 1:200,000 EPI
What can you give for uterine relaxation for internal manipulation?
NTG 100mcg initially and repeat to max of 500mcg
Signs and symptoms of uterine rupture
-Sudden abdominal pain despite functioning epidural
-vaginal bleeding
-HoTN
-cessation of labor
-fetal distress (most reliable sign)
-increased risk of postpartum hemorrhage
-DX: manual exploration/laparotomy
What are the risk factors for uterine rupture?
-Previous uterine surgery
-trauma
-multiparity
-uterine anomaly
-oxytocin
-placenta percreta
-tumors
-macrosomia
-malposition
What is the most common abnormal presentation?
longitudinal-vertex or breech
What abnormal presentations have the greatest chance of uncomplicated spontaneous vaginal delivery?
Vertex
flexed c-spine (chin to chest)
occiput anterior (face down)
What are the different Breech positions?
-complete
-frank
-incomplete (footling)
over 90% of breech infants are delivered via c-section
What are the risks of abnormal fetal presentation?
-increased risk of fetal death
-asphyxia
-birth trauma
-cord prolapse
-maternal infection (d/t internal manipulation)
What fetal position is an absolute indication for c-section
transverse lie
How many weeks is considered postmaturity?
-Gestation beyond 42 weeks
risks evident at 40-41 wks.
What are the complications of postmaturity?
-decreased uteroplacental blood flow= fetal distress
-umbilical cord compression d/t oligohyramnios
-Meconium staining of amniotic fluid
-increased incidence of macrosomia and shoulder dystocia
Anesthetic considerations for postmaturity
Labor and delivery – epidural analgesia, preparations for c-section due to cephalopelvic disproportion
C-section – as usual – epidural/spinal as needed with usual risks and precautions
What are some causes of Intrauterine fetal demise (IUFD)?
-chromosomal abnormalities
-congenital malformations
-multiple gestations
-infection
-cord accidents
-placental factors
-maternal immunological / thyroid disease
-isoimmunization
-maternal trauma
consider epidural for L&D - can develop DIC w prolonged retention of fetus
How long do you typically have during a prolapsed umbilical cord before fetal compromise?
10 mins!
At what cord length is there a risk of compression, constriction and rupture?
< 30 cm
At what cord length is there a risk of cord entanglement?
> 72 cm
What is the most common cause of postpartum maternal palsy?
cephalopelvic disproportion
results in lumbosacral trunk compression as it crosses the pelvic brim by the fetal head
What are the reasons for new onset backache during pregnancy?
-increased lumbar lordosis
-increased laxity of sacrococcygeal, sacroiliac, and pubic joints