Complications of Anesthesia Flashcards

1
Q

Complications related to delivery of anesthesia:

Evaluate, Manage, Document.
Is it ok to go back later and change your documentation?

A

HELLS NO. It looks incriminating. Document as closely to the time it happened as you can. Be specific, concise, descriptive. Cover you ass!

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2
Q

What is the American Society of Anesthesiologists Closed Claims Project?

A

They look at closed claims and identify patterns, potential liabilities, and strategies for prevention of claims/complications.

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3
Q

What are the top 3 claims identified by the ASA?

A
  • Death- 22%
  • Nerve injury -18%
  • Brain damage -9%

Emerging areas of claims are in regional anesthesia, Chronic Pain Management, and Acute pain.

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4
Q

Drawn-up drugs in a syringe need to have the following items labeled:

A
  • Drug name
  • concentration (%) and/or mg/mL
  • Date drawn up
  • Expiration date/time
  • initials of who drew up the drug
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5
Q

What is anesthesia awareness?

A

It’s not like breast cancer awareness.

Bad news: It’s being able to recall events while under anesthesia signifying that either the person was not “deeply” enough sedated or may have a physiologically resistance to anesthetics.

Good news: incidence rate of 0.2%-0.4% of people.

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6
Q

What surgical settings are associated with awareness?

A
  • Major Trauma 43%: no gas, too hypotensive
  • Obstetrics 1.5%: Emergent C-section
  • Cardiac Surgery 0.4% -sternotomy is very stimulating, many nerves in the area.
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7
Q

Prevention of intraoperative recall/awareness:

In addition to using volatile anesthetic agents at a MAC level consistent with amnesia, what other drugs can help with amnesia?

A
  • Benzodiazepines- Antegrade amnesia (point of administration forward)
  • Scopolamine- Retrograde Amnesia (when given in IV form, not the patch, rarely given)
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8
Q

Eye injuries:

What is the most common and most serious cause of post operative vision loss? How does it happen?

A

Ischemic Optic Neuropathy (ION)

-optic nerve infarction due to decreased oxygen delivery via one or more arterioles supplying the optic nerve.

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9
Q

Ischemic Optic Neuroapthy (ION) is commonly reported after what kind of surgeries? Are there any conditions that contribute to intra/post operative ION?

A
  • cardiopulmonary bypass (hypotension- inadequate profusion to the eyes)
  • radical neck dissection
  • abdominal and hip proceedures
  • spinal surgeries in prone position or any prone surgery.

Contributing conditions: HTN, DM, CAD, Smoking

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10
Q

T/F: ION onset is immediate or can be delayed through 12th day post op and range from decreased visual acuity to complete blindness.

A

T-R-U-E

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11
Q

How can one prevent ION in patient?

A
  • enhance venous outflow by position the patient head up.
  • minimize abdominal constriction.
  • monitor BP carefully with arterial line
  • limit degree and duration of deliberate hypotension
  • avoid anemia in patients at risk for ION
  • consider staging long surgical procedures in patients at risk of ION. (multiple surgeries instead of 1 long surgery.
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12
Q

Cardiopulmonary arrest during spinal anesthesia is associated with a block that reaches what dermatome level?

A

T4 or above. T4 is at the nippleline. T7 (Xyphoid process) is the target level for a typical spinal.

-T2, T3, T4 are the cardiac accelerators.

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13
Q

Cardiopulmonary arrest during spinal anesthesia:

What are signs and symptoms prior to arrest?

A
  • Gradual decline in HR and BP (20% below baseline values)
  • Bradycardia
  • Hypotension (also typical in a normal spinal)
  • Cyanosis
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14
Q

Cardiopulmonary arrest after spinal anesthesia:

What is the treatment for cardiopulmonary complications?

A
  1. Ventilatory support (bag/mask and O2)
  2. Ephedrine- first choice bradycardia and BP support
  3. Atropine to treat bradycardia
  4. Epinephrine in small doses 5-10mcg for bradycardia that is unresponsive to atropine and ephedrine.
  5. CPR if loss of pulses and use ACLS protocols and doses of Epinephrine (1mg).
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15
Q

What is the cause and treatment of hearing loss after spinal anesthesia?

A

Due to CSF leak, treated with blood patch.

Often accompanied by spinal headache.

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16
Q

After general anesthesia, what are causes of hearing loss?

A
  • Surgical manipulation
  • Middle ear barotrauma
  • vascular injury
  • ototoxicity of drugs
  • s/p cardiopulmonary bypass
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17
Q

Allergic reactions:

What is an allergic reaction?

A
  • Exaggerated immunologic responses to antigenic stimulation in a previously sensitized individual.
  • The allergen may be the substance itself, its metabolite or a breakdown product of the substance.
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18
Q

Allergic reactions:

T/F: An allergen (ie. latex) may cause more than one type of reaction.

A

True

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19
Q

Allergic reactions:

What is a Type I- Immediate reaction?

A

Most serious, includes :

  • atopy (genetic predisposition towards developing allergies)
  • Examples include anaphylaxis and allergic rhinoconjunctivitis.
  • involve immunoglobulin E (IgE)–mediated release of histamine and other mediators from mast cells and basophils.
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20
Q

Allergic reactions:

What is a Type II-Cytotoxic reaction?

A
  • involve immunoglobulin G or immunoglobulin M antibodies bound to cell surface antigens, with subsequent complement fixation.
  • Examples: drug-induced hemolytic anemia, hemolytic transfusion reactions and heparin-induced thrombocytopenia.
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21
Q

Allergic reactions:

What is a Type III-Immune Complex reaction?

A
  • involve circulating antigen-antibody immune complexes that deposit in postcapillary venules, with subsequent complement fixation.
  • Example is serum sickness, RA
22
Q

Allergic reactions:

What is a Type IV-Delayed, cell-mediated reaction?

A
  • are mediated by T cells rather than by antibodies.

- An example is contact dermatitis from poison ivy or nickel allergy.

23
Q

What type of reaction is anaphylaxis?

A
  • Exaggerated response to an allergen that is mediated by a Type I hypersensitivity.
  • Appears within minutes of exposure to a specific antigen in a sensitized individual.
24
Q

What are the common clinical manifestations of anaphylaxis?

A

CV: Hypotension and tachycardia (circulatory shock)

Pulmonary: Bronchospasm, cough, wheezing/stridor dyspnea, pulmonary edema, laryngeal edema, hypoxia

Dermatologic: urticaria, facial edema, pruritus

25
Q

What inflammatory mediators are released during an anaphylactic reaction?

A

Histamine-
Leukotrienes
BK-A
Platelet-activating factor

26
Q

What are anaphylactoid reactions?

A

Resembles anaphylaxis but does ot depend on IgE interaction with antigen.

27
Q

How is treatment for an anaphylactoid reaction different than treatment for an anaphylactic reaction?

A
  • There is no difference in treatment.

- One cannot tell the difference as both have the same general symptoms.

28
Q

What are risk factors associated with hypersensitivity to anesthetics?

A
  • Female
  • Atopic history (genetic predisposition towards developing allergies.
  • preexisting allergies
  • previous anesthetic exposure (Sensitization)
29
Q

What are the treatments for anaphlactoid and anaphylactic reactions?

A
  • Discontinue drug administration
  • administer 100% O2
  • Epinephrine (0.01-0.5mg IV or IM) to treat Hypotension
  • Consider intubation or trach (assess airway)
  • IV fluids (1-2 liters LR)
  • Diphenhydramine (50-75mg IV or IM) antihistamine
  • Ranitidine (150mg IV) H2 blocker
  • Hydrocortisone (up to 200mg IV or methylprednisolone (1-2mg/kg) to depress immune reaction.
30
Q

What anesthetic drug is most commonly responsible for anaphylactic reactions?

A

Muscle relaxants, account for 70% of reactions.

Rocuronium is most common, then succinylcholine and atracurium. Roc and many cosmetics contain the same ingredients. Females may be more sensitized to Roc.

31
Q

T/F: Opioid reactions rarely anaphylactic and most are non-immune related histamine release.

A

True

Also true: patient’s love and are not allergic to that one that starts with a “D”

32
Q

T/F: Volatile inhaled agents only cause anaphylactoid reactions.

A

False. In fact, there are no documented cases on anaphylaxis from the volatile agents.

33
Q

Which family of local anesthetics causes the majority of allergic reactions?

A

The Ester type local anesthetics.

  • Share common antigenicity with PABA, cross reactivity with other ester type anesthetics should be suspected. Use an Amide if patient has an ester allergy.
  • Amide type local anesthetic rarely cause anaphylaxis. If they do, it’s due to paraben or methylparaben.
34
Q

What is the 2nd most common cause of anaphylaxis?

A

Latex allergy

Can have a type I and/or Type IV reaction to latex.

35
Q

Foods that cross react with latex are:

A

Mango, banana, kiwi, avocado, passion fruit and chestnut. Bummer!!

36
Q

What is MH?

A

Malignant hyperthermia is a rare, inherited myopathy, characterized by an acute hypermetabolic state in muscle tissue after induction of general anesthesia.

37
Q

What is the 1st indicator of MH?

A

Unexplained and rapidly increasing EtCO2

38
Q

T/F: If a person has no prior problems with anesthesia, they cannot develop MH.

A

False. It an happen after having prior anesthesia without complications.

39
Q

Hyperthermia is an early sign of MH?

A

No, it is a late sign. Watch the EtCO2 and signs of hypermetabolic activity, acidosis, etc.

40
Q

MH is characterized by an uncontrolled increase in intracellular _______ in skeletal muscle.

A

Calcium.

The sudden release of Ca from the Sarcoplasmic reticulum removes the inhibition of troponin and causes intense muscle contractions.

41
Q

What drugs are known to trigger MH?

A
  • Halogenated general anesthetics

- non-depolarizing muscle relaxants: Succinylcholine

42
Q

What is the dose of dantrolene to be administered?

A

2.5mg/kg q 5 minutes to max dose of 10mg/kg. continuous infusion of dantrolene should be given for 24 hours.

43
Q

How does dantrolene work?

A

Directly interferes with muscle contraction by binding to Ryr1 receptor, calcium channel and hihibiting Ca ion release from sarcoplasmic reticulum.

44
Q

What is a laryngospasm?

A

Complete spasmodic closure of the larynx as a consequence of an outside stimulus. Closure of the glottis as a result of reflex constriction of the laryngeal muscles.

45
Q

What is a common cause of laryngospasm at induction?

A

Inadequate onset of muscle relaxant.

46
Q

how can one break a laryngospasm?

A

Positive pressure ventilation usually breaks a spasm.

47
Q

What is a Bronchospasm?

A

Spasmodic constriction of bronchial smooth muscle creates narrowing of airway passages and increases airway resistance.

48
Q

During a Bronchospasm is a patient difficult or easy to ventilate?

A

Difficult. Tight respirations. will feel resistance to bagging.

49
Q

how does a bronchospasm manifest?

A
  • Prolonged expirations.
  • high inflation pressures
  • expiratory wheezes
  • decreased oxygen saturation
  • difficult to bag-mask. resistance to bagging.
50
Q

what is one way to break a bronchospasm?

A

Deepen anesthesia by increasing the gases.

gases=bronchodilators.

51
Q

Radiation exposure in the OR:

Maximum occupational whole body exposure to to radiation per year is ____rem/year.

A

5.

wear lead aprons and stand back if possible. Exposure at 4 meters will be 1/16th the exposure at 1 meter distance.