Complications in OB Flashcards
“Term for singleton pregnancy is ____ completed weeks to ____ weeks.
37-42
pre-term labor: regular uterine contractions occurring at least q___ min resulting in cervical change prior to ___ weeks.
q10
37 weeks
Very low birth weight (VLBW)
any infant < 1500g.
Low birth weight (LBW)
any infant < 2500g at birth.
Respiratory Distress Syndrome: Exacerbated by…..
intrapartum hypoxia, maternal stress
Almost all infants <27 wks GA, almost 0% by 36 wks GA.
Cause of Intracranial Hemorrhage
Uncontrolled delivery/trauma, neonatal HTN.
Association of PTL with genital tract colonization with :
Group B Strep, Neisseria gonorrhoeae, and bacterial vaginosis organisms.
C-section or vaginal delivery?
Concern regarding intracranial hemorrhage:
No difference
C-section or vaginal delivery?
Obstetrician use of outlet forceps to assist delivery :
no difference
C-section or vaginal delivery?
Breech:
C-section is proven safer in PTL with breech presentation
Will do scheduled c section with breech
What is Tocolylitic therapy?
Attempt to stop or slow contractions to avoid PTL.
Reasons for tocolytic therapy:
Gestational age 20-34 wks, EFW < 2500 g, absence of fetal distress.
How long can Tocolytic therapy be used?
Used for short-term (<48 hrs),
to permit corticosteroid treatment to aid fetal lung maturation, or allow transfer to a facility with appropriate NICU facilities.
Methylxanthines: how does Phosphodiesterase work?
increase intracellular cAMP —> uterine muscle relaxation.
Tocolytic Therapy: Calcium Channel Blockers (Nifedipine) MOA…
Myometrium contractility related to free calcium concentration: decrease in Ca2+ —->decrease contractility.
Maternal side effects of CCBs
-Hypotension, tachycardia, dizziness, palpitations
-Facial flushing
-Vasodilation, peripheral edema
-Myocardial depression, conduction defects
-Hepatic dysfunction
-Postpartum hemorrhage
-Fetal side effects
-Decreased UBF –>fetal hypoxemia and fetal acidosis
LOTS!
Calcium Channel Blockers may increase risk of_______ _________ due to uterine atony refractory to ________ and _________ F-α2
postpartum hemorrhage
oxytocin and prostaglandin F-α2
Tocolytics: Prostaglandin Synthetase Inhibitors MOA
Mechanism of action: decrease cyclooxygenase ———> decrease prostaglandin
TOCOLYTIC THERAPY: Magnesium MOA
-May compete with calcium for uterine smooth muscle surface binding —–> decrease contractility.
-Prevents increase in intracellular calcium.
-Activates adenylcyclase —–> increase cAMP.