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Biochemistry Exam 2 > Complex Lipids > Flashcards

Complex Lipids Flashcards

0
Q

What receptor specifically mediates uptake of intact LDL?

A

LDL (apoB/E) receptor

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1
Q

What is the rate limiting step of cholesterol metabolism?

A

LDL (apoB/E) receptor specifically mediates uptake of intact LDL

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2
Q

What are the two primary bile acids?

A

Cholic acid and chenodeoxycholic acid

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3
Q

What is the rate limiting enzyme for bile acid synthesis?

A

7 alpha-hydroxylase enzyme

CYP7A1

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4
Q

What does 7 alpha-hydroxylase do?

A

Places a hydroxyl group at the 7-alpha position of a cholesterol ring.

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5
Q

Where do secondary bike acids form?

A

Intestine

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6
Q

What type of bacteria forms secondary bike acids?

A

Bacteriodes bacteria

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7
Q

What are the three groups of steroid hormones?

A

Corticosteroids
Androgens
Estrogens

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8
Q

What is the structure of corticosteroids?

A

21 carbons atoms with basic pregnane ring

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9
Q

What is the structure of androgens?

A

19 carbon atoms with androstane ring

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10
Q

What is the structure of estrogens?

A

Loss of methyl group at carbon 19 (aromatization of A ring) produces estrane structure

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11
Q

What is the primary starting material for synthesis of phosphatidic acid?

A

Glycerol-3-Phosphate

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12
Q

Glycerol 3 phosphate is the primary starting material for the synthesis of what?

A

Phosphatidic acid

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13
Q

What are the 2 alcohol containing phospholipids?

A

phosphatidylGLYCEROL
And
PhosphatidylINOSITOL

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14
Q

If we add a second phosphatidic acid to phosphatidylGLYCEROL, what do we make?

A 
Cardiolipin 
Aka diphosphatidylglycerol (DPG)
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15
Q

Where is cardiolipin found?

A

Inner mitochondrial membrane

16
Q

Cardiolipin represents ___% of the phospholipids in _______ ______.

A

20%

Heart mitochondria

17
Q

What is the first major class of mitochondrial lipids?

A

Cardiolipins (DPG)

18
Q

What are the three classifications of glycolipids (aka glycosphingolipids)?

A

Cerebrosides
Sulfatides
Gangliosides

19
Q

Cerebrosides are found…

A

Muscle nerve cell membrane

20
Q

Sulfatides are found…

A

CNS

21
Q

Gangliosides are found…

A

Autoimmune

Biochemistry Exam 2 (4 decks)

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