complex lipid metabolism Flashcards
where are most phospholipids synthesized
smooth ER (distributed by exocytosis)
what are the predominant lipids of cell membranes
phospholipids
what are the two types of phospholipids
glycerolphospholipids
spingophospholipids
what are the three characteristics of phosphatidic acid
glycerol backbone
2 fatty acyl groups
phosphate group
what are the 4 characteristics of sphingophospholipids
sphingosine backbone
long-chain FA at carboxyl group
long chain desaturated group
phosphate group
what is the structure of a plasmalogen?
a phosphatidic acid w/ an unsaturated alkyl group at carbon 1
what is the significant plasmalogen in nerve tissue?
phosphatidalethanolamine
what is the significant plasmalogen in heart muscle?
phosphatidalcholine
what is the purpose of PAF (platelet-activating factor)
it triggers potent thrombotic and acute inflammatory events
where is cardiolipin found in eukaryotes?
virtually exclusive to the inner mitochondrial membrane
what are three important functions of sphingomyelin?
precursor of glycolipids
only significant sphingophospholipid in humans
important for myelin nerve fibers
what are the 2 things needed to synthesize phosphatidic acid?
glycerol phosphate
two fatty acyl CoA
what part of the body cannot synthesize phosphatidic acid?
RBCs
what are the primary sources of choline and ethanolamine?
diet
phospholipid turnover
phosphatidylcholine is secreted as what from the liver?
a component of serum lipoproteins
bile