Complex Genetic Disorders Flashcards
1
Q
What are the three types of obesity?
A
Syndromic, Monogenic and Common
2
Q
What is syndromic obesity commonly accompanied by?
A
Mental Retardation
Dysmorphic features
3
Q
Describe the action of leptin.
A
Leptin is produced by adipocytes and travels to the brain to let the brain know how much fat is stored in the adipose cells and thus regulates feeding
4
Q
What are some features of leptin deficiency?
A
Low thyroid function
Immune problems
Incomplete/lack of puberty
5
Q
What is the treatment for leptin deficiency?
A
Recombinant leptin
6
Q
Name some genes that cause monogenic obesity.
A
POMC
PCSK1
MC4R
MRAP2
7
Q
What are Genome Wide Association Studies used for in relation to obesity?
A
To identify single nucleotide polymorphisms that are associated with obesity e.g. FTO
