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IMMUNO SERO > Complement System > Flashcards

Complement System Flashcards

1
Q

Activates classical pathway

A

IgG, IgM

IgM being the most potent one,
IgG in decreasing order: 3,1,2

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2
Q

Activates alternative pathway

A

Microbe surface molecules

Also IgA

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3
Q

Lectin pathway is activated by

A

Mannose or other sugars on microbe surface

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4
Q

Funtions as Anaphylactoid

A

C4a, C5a, C3a

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5
Q

Functions as opsonin

A

C3b, inactive C3

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6
Q

Deficiency of this complement component will result in hereditary angioneurotic edema

A

C1 esterase inhibitor

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7
Q

Deficiency of this complement component is linked to recurrent neisserial infections

A

C5-C8

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8
Q

Deficiency of this complement component has no known associated dse

A

C9

C-NINE (C-NONE)

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9
Q

Most common complement deficiency

A

C2

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10
Q

Most severe complement deficiency and associated to severe recurrent infections and glomerulonephritis

A

C3

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11
Q

Deficiency of these complement components are associated to PNH

A

CD59/ MIRL

CD55/ DAF

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12
Q

Dissociates C1r and C1s from C1q

A

C1 inhibitor

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13
Q

Increases the dissociation of c3 convertase

A

DAF

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14
Q

Inhibits MAC formation

A

MIRL/CD 59

MIRL: membrane inhibitor of reactive lysis

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15
Q

Prevents attachment of C5bC6C7 to cell membrane

A

Vitronectin

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16
Q

Activates C1s

A

C1r

17
Q

Binds to Fc of IgM or IgG

A

C1q

18
Q

Cleaves C4 and C2

A

C1s

19
Q

Starts pore formation

A

C8

20
Q

Initiates MAC

A

C5

21
Q

KEY INTERMEDIATE, INVOLVED IN ALL PATHWAY

A

C3

Most severe complement deficiency

22
Q

Stabilizes C3 convertase in the Alternative pathway

A

Properdin

23
Q

Cleaves factor B in alternative pathway

A

Factor D

24
Q

C3 convertase in the Classical pathway

A

C4b2a

25
Q

C3 convertase in alternative pathway

A

C3bBb P

P: properdin, stabilizes C3 convertase of the alternative pathway

26
Q

C5 convertase of alternative pathway

A

C3bBbP3b

27
Q

C5 convertase of Classical pathway

A

C4b2a3b

Also of the mannose pathway

28
Q

Helps cleave C4and C2 in the Lectin pathway

A

MASP-1

29
Q

CLEAVES C4 and C2 IN LECTIN PATHWAY

A

MASP-2

30
Q

Recognition unit

A

C1

31
Q

Activation unit

A

C4, C2, C3

32
Q

Membrane attack complex

A

C5-C9

33
Q

CRITICAL STEP IN THE FUNCTIONING OF THE COMPLEMENT SYSTEM

A

Activation of C3

34
Q

Deficiency of this inhibitor causes excessive complement activation and form the basis of development of hereditary angioneurotic edeme

A

C1 esterase inhibitor

C1 esterase inhibitor blocks the binding of C1 to immune complex

IMMUNO SERO (3 decks)

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