Complement System

Question 1

What combination will take up an added complement ?

Answer 1

Ab Ag plus a fixed amount of pre-titrated complement where if the Ag and Ab are specific to one another they will combine

Question 2

C1 and c4 are involved in ?

Answer 2

Neutralisation of viruses

Question 3

Complement mediates the attack on invading microorganisms. True or False ?

Answer 3

True

Question 4

What is the function of antibodies ?

Answer 4

1) identify the invading organisms as foreign
2) activate the attack of complements

Question 5

C3 and C5 are involved in ?

Answer 5

Inflammation response

Question 6

What is the most important thing in complement fixation test ?

Answer 6

The sequence of the reaction that leads to damage of cell membranes

Question 7

For complement fixation test, what temp and time should serum be heated for ?

Answer 7

30 minutes at 56°C

Question 8

What are the processes the complement system sets in motion to destroy foreign cells ?

Answer 8

1) cell lysis
2) opsonization
3) inflammation

Question 9

What complement binds ro microbes where neutrophils and macrophages have specific binding sites for it ?

Answer 9

C3

Question 10

Membrane dange that can cause destruction of bacteria by rupture, so that the cells release their contents is described as ?

Answer 10

Cell lysis

Question 11

Activation of the complement system can lead to ?

Answer 11

1) Production of biologically active factors
2) pathological processes
3) Damage of cell membrane

Question 12

Testing for the presence of free, unattended complements is done by ?

Answer 12

Addition of RBC’s sensitised with haemolysis

Question 13

What 2 distinct reactions does complement fixation test depend on ?

Answer 13

1) Ag-Ag + a fixed amount of pre-titrated complement. Where if the Ag and Ab are specific to each other they will combine

2) testing for the presence of free, unattended components

Question 14

Complement system is activated by ?

Answer 14

Ig-M and Ig-G

Question 15

Explain cell lysis

Answer 15

The full complement system leading to membrane damge can cause the destruction of some bacteria by rupture, so that the cells release their contents

Question 16

Explain inflammation

Answer 16

Chemotaxis of phagocytic cell towards the microbes and the increase in vascular permeability that is seen as a function of acute inflammation are products of the release of small fragments of complement components during the course of activation

Question 17

Explain opsonization

Answer 17

The activated C3 molecules bond to microorganisms where neutrophils and macrophages have specific binding sites for C3, thus facililitating phagocytosis of the coated organisms

Question 18

Tissue transplantation ?

Answer 18

The process of transferring tissues or organs from one site to another