Complement Cascade Flashcards
1
Q
What is the difference between the classical and alternative pathways of complement activation?
A
The classical pathway is activated by antibodies and starts with C1, the alternative pathway is activated by pathogens and starts with C3.
2
Q
What happens when C3 cleaves?
A
C3a and C3b are produced. C3b opsonises pathogens to facilitate phagocytosis. C3a forms a complex with C5a which causes the degranulation of mast cells, chemotaxis, and an increase in vascular permeability.
3
Q
What are the outcomes of the complement cascade?
A
Chemotaxis, membrane attack complex formed, opsonisation and agglutination, oedema.
4
Q
What the process called where immune cells crawl out of blood vessels through gaps in the blood vessels, and into the tissues?
A
Diapedesis.
