Competitive and Non-competitive inhibitors

Question 1

What is enzyme inhibition?

Answer 1

The reduction in the rate of an enzyme-controlled reaction by another molecule

Question 2

What does the inhibitor combined with?

Answer 2

Enzyme

Question 3

What is the purpose of the inhibitor?

Answer 3

Either directly or indirectly prevents it form forming an enzyme-substrate complex

Question 4

What are the 2 types of inhibitors?

Answer 4

Competitive
Non-competitive

Question 5

What are competitive inhibitors?

Answer 5

Similar in shape to a substrate

Question 6

Describe how competitive inhibitors decreases the rate of reaction

Answer 6

Are complementary to the enzyme active site and bind to it
Blocks the actual substrate from entering the active site
Less enzyme-substrate complexes can form
Rate of reaction decreases and less product is produced
If concentration of substrate increases, the effect of the inhibitor is reduced

Question 7

What are non-competitive inhibitors?

Answer 7

Not a similar shape to the substrate

Question 8

What do non-competitive inhibitors bind to?

Answer 8

The allosteric site
Binds to the enzyme at a point other than the active site

Question 9

What does the non-competitive inhibitor do to the enzyme?

Answer 9

Changes its shape and therefore changes the shape of the active site
No longer complementary to the substrate
Enzyme molecule may be permanently damaged