Competitive and Non-competitive inhibitors Flashcards

1
Q

What is enzyme inhibition?

A

The reduction in the rate of an enzyme-controlled reaction by another molecule

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2
Q

What does the inhibitor combined with?

A

Enzyme

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3
Q

What is the purpose of the inhibitor?

A

Either directly or indirectly prevents it form forming an enzyme-substrate complex

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4
Q

What are the 2 types of inhibitors?

A

Competitive
Non-competitive

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5
Q

What are competitive inhibitors?

A

Similar in shape to a substrate

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6
Q

Describe how competitive inhibitors decreases the rate of reaction

A

Are complementary to the enzyme active site and bind to it
Blocks the actual substrate from entering the active site
Less enzyme-substrate complexes can form
Rate of reaction decreases and less product is produced
If concentration of substrate increases, the effect of the inhibitor is reduced

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7
Q

What are non-competitive inhibitors?

A

Not a similar shape to the substrate

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8
Q

What do non-competitive inhibitors bind to?

A

The allosteric site
Binds to the enzyme at a point other than the active site

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9
Q

What does the non-competitive inhibitor do to the enzyme?

A

Changes its shape and therefore changes the shape of the active site
No longer complementary to the substrate
Enzyme molecule may be permanently damaged

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