Comp Exam Flashcards
Na/K Pump
3 Na OUT; 2 K IN
Local Potential - Temporal
STEPWISE Fashion
Local Potential - Spatial
SEVERAL at SAME TIME
End of Cord
L2
Cauda Equina
L2-S5
Lateral Horns
T1-L2
Posterior Intermediate Sulcus
C1-T2
Rexed Laminae 2
PAIN;
substanita gelatinosa
Rexed Laminae 3 & 4
DISCRIMINATIVE touch; CONSCIOUS proprioception;
nucleus proprius
Rexed Laminae 7
UNCONSCIOUS proprioception,
nucleus dorsalis/Clark’s column
Dorsal Column
Discriminative touch, conscious proprioception
Spinothalamic
Conscious pain/temp
Spinoreticular
Arousal, unconscious pain
Spinocerebellar
Unconscious proprioception
Lateral Corticospinal
Voluntary movement; fine motor
Rubrospinal
Gross motor
Reticulospinal
Trunk and posture
Vestibulospinal
Trunk and posture
Tectospinal
Reflexive turning of head
Quadraplegic
C1-T1
Paraplegic
T1/2 Down
Anterior Cord Injury
Ventral lost, dorsal intact
NO pain/motor/light touch/proprioception/deep pressure
Central Cord Injury
Medial lost;
UE > LE weakness
Brown Sequard Injury
Half lost
NO ipsi light touch/vibration; contral temp
Autonomic Dysreflexia Risk
T6 and above
SNS output
thoracolumbar
PNS output
cervicosacral
Thalamus nuclei: anterior
emotional tone
Thalamus nuclei: dorsomedial
judgement/reasoning
Thalamus nuclei: ventral anterior
motor planning/regulation
Thalamus nuclei: ventral lateral
motor output regulation
Thalamus nuclei: ventral posterior
somatosensory and vestibular information
Thalamus nuclei: LGN
relay to primary visual [17]
Thalamus nuclei: MGN
relay to primary auditory [41]
BG Loop: striato-pallido-thalamic
motor
BG Loop: dorsolateral prefrontal
executive function
BG Loop: lateral orbitofrontal
empathy/social appropriateness
BG Loop: Anterior cingulate
procedural learning
BG Loop: Direct
facilitates movement via internal GP, + feedback
BG Loop: Indirect
inhibit movement via external GP, - feedback
Climbing Fibers
Teach purkinje cells how to response to particular patterns of movement from mossy/parallel fiber input
Broca’s Area
L = motor program of speech R = nonverbal, gestures, tone
Wernicke’s Area
L = comprehension of speech R = nonverbal, spatial relationship
Semicircular canal
ANGULAR movement
Otolith
LINEAR movement [utricle = horizon; saccule = vert]
M1
primary simple movement of hand/face
PMA
complex multi-joint movement that is coordinated
PMCd
large proximal mm
PMCv
hand shape
SMA
sequential movement and bilat coordination
Stroke: face droop, dead arm, dysarthria, dysphagia
MCA
Stroke: LE weakness, difficulty standing
ACA
Stroke: impaired judgement, impulsivity, neglect, visual deficits, hemiparesis
Right
Stroke: language deficits, aphasia, apraxia, processing delay, perseveration, hemiparesis
Left
CT
good contrast resolution
specific and sensitive
Xray
specific, not sensitive
MRI
sensitive, no specific
T1 MRI
parallel, bone, anatomical
T2 MRI
perpendicular, water, pathology
ABCs of radiology
Alignment, Bone density, Cartilage, Soft tissue
Therapeutic Index
LD50/ED50; HIGHER # = SAFER
Absorption
best with small, lipid soluble, polar molecules
Pharmokinetics
absorption, distribution, biotransformation, excretion
Pharmacodynamics
effect at target site
HTN meds [5]
beta blocker, alpha blocker, Ca blocker, diuretics, ACE inhibitor
Anti-arrhythmia meds [4]
Na blocker, beta blocker, K blocker, Ca blocker
MAOI
prevent dopamine breakdown
Mm relaxors
Baclofen [bind to GABA]; Botox [inhibit Ach]
Cancer drug that causes foot drop
Vincristine
Transcription
DNA > RNA
Translation
RNA > protein
Anaerobic vs. Aerobic Respiration
An = 2 ATP, A = 34 ATP
B cells
humoral immunity
bone marrow
antibodies
T cells
cell mediated immunity
thymus
NK cells
Hypersensitivity Types
ABCD 1 = allergic 2 = antibody [blood] 3 = immune complex [clumps] 4 = cell mediated [delay]
Hashimoto’s
HYPOthyroidism, goiter, weight gain, cold intolerance
Grave’s
HYPERthyroidism, exopthalamus, weight loss, heat intolerance
OCD
obsessive = repeated behavior compulsive = MUST react immediately
ADHD
hyperactive, inattentive, impulsive
Cancer warning signs
Night pain Can't alleviate pain Deep ache Diffuse Weakness Fatigue