COMP Flashcards
IL-1
Made by: 3
Acts to: 2
Made by: Macs, DCs, endo cells
Acts to: Activate epi and attract PMNs. Induces syn of acute phase proteins in liver
induces fever (pyrogenic)
IL-6
Made by: 2
Acts to: 1
Made by: Macs, endo
Acts to: Stimulate production of acute phase proteins
IL-8
Made by: 3
Acts to: 1
Made by: Macs, epi- endo
Acts to: Chemoattractant for neuts
TNF-a
Made by: 2
Acts to: 2
Made by: Macs, Th1
Acts to: Activate endo and neuts
INF-a/b
Made by: 3
Acts to: 3
Made by: Infected epi cells, macs, dends Acts to: Inhibits viral replication, upregulates MHC class I, activates NKs
IL-12
Made by: 1
Acts to: 3
Made by: Macs (APCs)
Acts to: Activates Th to become Th1, activates NK cells, enhances cytotoxicity of NK cells and CTLs
IL-2
Made by: 1
Acts to: 2
Made by: Activated T cells
Acts to: T cell proliferation, enhances NK killing and proliferation
INF-g
Made by: 3
Acts to: 4
Made by: Th1 in response to IL-12. Activated NK cells and CTLs. Acts to: Activates Macs, B cells class switch to IgG2. Increases Ag processing and presentation, inhibits Th2
IL-4
Made by: 2
Acts to: 2
Made by: Th2, activated mast Acts to: B cells class switch to IgE, inhibits Macs and Th1
IL-5
Made by: 2
Acts to: 2
Made by: Th2 cells, activated mast cells Acts to: Activates eosinophils, B cell class switch to IgA
IL-6
Made by: 2
Acts to: 1
Made by: Th2 cells, activated mast cells
Acts to: GF for B cells
IL-13
Made by: 1
Acts to: 2
Made by: Th2 cells
Acts to: B cell switch to IgE, alternative activation for Macs
IL-17/22
Made by: 1
Acts to: 1
Made by: Th17
Acts to: Attract and activate neutrophils
IL-10
Made by: 5
Acts to: 3
Made by: T regs, Th2, Macs, DCs, monocytes
Acts to: Suppress macs, inhibit Lcyte proliferation, induces T cell anergy
TGF-b
Made by: 1
Acts to: 3
Made by: T regs
Acts to: Shut down Th1 response, induces Th17 differentiation, isotype switching to IgA in MALT
