Common Teratogenic Drugs

Question 1

Drug - Effect: Alcohol

Answer 1

1) Fetal alcohol syndrome 2) Microcephaly 3) CHD

Question 2

Effect - Drug: Mesomelia, cranial dysplasia

Answer 2

Aminopterin

Question 3

Effect - Drug: Hypoplastic nasal bridge, chondrodysplasia punctate

Answer 3

Coumarin

Question 4

Effect - Drug: Poor neonatal adaptation

Answer 4

Fluoxetin

Question 5

Effect - Drug: Cardiovascular, renal oral cleft defects, and NTDs

Answer 5

Folic acid antagonists

Question 6

Drug - Effect: Isotretinoin AND Vitamin A

Answer 6

Facial and ear anomalies, CHD

Question 7

Effect - Drug: Ebstein anomaly

Answer 7

Lithium

Question 8

Effect - Drug: Microcephaly, blindness, deafness, retardation (Minamata disease)

Answer 8

Methyl mercury

Question 9

Effect - Drug: Arthrogryposis

Answer 9

Misoprostol

Question 10

Effect - Drug: Cutis lava syndrome

Answer 10

Penicillamine

Question 11

Effect - Drug: Phenytoin

Answer 11

1) Hypoplastic nails 2) IUGR

Question 12

Effect - Drug: Radioactive iodine

Answer 12

Fetal hypothyroidism

Question 13

Drug - Effect: Radiation

Answer 13

Microcephaly

Question 14

Drug - Effect: DES

Answer 14

Vaginal adenocarcinoma during adolescence

Question 15

Drug - Effect: Streptomycin

Answer 15

Deafness

Question 16

Drug - Effect: Testosterone-like drugs

Answer 16

Virilization of female

Question 17

Drug - Effect: Tetracycline

Answer 17

Enamel hypoplasia

Question 18

Drug - Effect: Thalidomide

Answer 18

Phocomelia

Question 19

Drug - Effect: Toluene (solvent abuse)

Answer 19

Fetal-alcohol like syndrome, preterm labor

Question 20

Drug - Effect: Valproate

Answer 20

Spina bifida

Question 21

Drug - Effect: Vitamin D

Answer 21

Supravalvular aortic stenosis