Common liver, gallbladder and pancreatic conditions Flashcards

1
Q

primary sclerosing cholangitis complications

A

acute bacterial cholangitis
cholangiocarcinoma
colorectal cancer
cirrhosis and liver failure

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2
Q

primary sclerosing cholangitis symptoms

A

jaundice
pruritis
RUQ pain
fatigue

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3
Q

primary sclerosing cholangitis investigations

A

GOLD STANDARD MRCP showing beaded appearance
p-ANCA, p-ANA
LFTs: raised ALP, rise in bilirubin

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4
Q

primary sclerosing cholangitis risk factors

A

Chrohn’s or UC
Male
30-40

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5
Q

primary sclerosing cholangitis
pathophys

A

intra and extra hepatic bile ducts become inflamed and scarred, narrowed and blocked (as oppose to PBC which is only intra)

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6
Q

acute cholecystitis treatment

A

cholecystectomy and imaging

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7
Q

Murphy’s sign

A

pressing down on gallbladder while patients breathes out: will cause pain

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8
Q

acute cholecystitis treatment

A

antibiotics and analgesia

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9
Q

acute cholecystitis symptoms

A

constant RUQ pain
fever
positive Murphys sign

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10
Q

risk factors for gall stones

A

5 Fs

fat
female
fertile
forty
family history

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11
Q

biliary colic definitive management

A

laparoscopic cholecystectomy (gall bladder removal)

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12
Q

biliary colic symptoms

A

colicky abdominal pain, worst after a fatty meal

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13
Q

biliary colic pathophys

A

stones in the cystic duct or common bile duct of the biliary tree

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14
Q

cholangitis features

A

patient severely septic and unwell
jaundice
ruq pain

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15
Q

cholangitis treatment

A

fluid resuscitation
broad spectrum IV antibiotics
correct coagulopathy

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16
Q

cholangitis pathophys

A

inflammation of the bile duct caused by gallstones or bacteria

17
Q

cholangitis features

A

patient severely septic and unwell
jaundice
ruq pain

18
Q

Primary biliary colangitis: 3 Ms

A

IgM
anti-Microbial antibodies M2 subtype
Middle age females

19
Q

isolated increase in bilirubin in response to physiological stress is due to…

A

Gilberts Disease

20
Q

What type of genetic pattern is Gilberts Disease

A

autosomal recessive

21
Q

what is deficient in Gilberts disease

A

UDP glucuronosyltransferase

22
Q

features of Gilberts disease

A

unconjugated hyperbilirubinaemia

23
Q

investigations of Gilberts disease

A

rise in bilirubin following fasting or IV nicotinic acid

24
Q

acute cholecystitis pathophys

A

progression of biliary colic to infection

25
Q

common causative bacteria of cholangitis

A

E COLI

26
Q

acute cholecystitis imaging

A

ultrasound first
then MRCP