Common drug classes + SEs Flashcards
Statin
HMG-CoA reductase inhibitors. Primary prevention of cardiovascular events
Muscle toxicity
Hypothyroidism
Interstitial lung disease
Corticosteroids
Glucocorticoid activity is anti-inflammatory; mineralocorticoid is fairly useless (just adrenocortical insufficiency, autonomic neuropathy).
Diabetes Osteoporosis Muscle wasting (proximal neuropathy) Central serous chorioretinopathy Cushing's syndrome (central body fat, esp 'buffalo hump', round flushed face, easily bruised skin)
Beta blockers
Angina, hypertension, arrhythmias, adjunct in heart failure
Erectile dysfunction
Bradycardia
Bronchospasm
Postural hypotension/syncope
ACE inhibitors
Heart failure, hypertension
Dry cough Hyperkalaemia Nephrotoxic (renal artery stenosis) (Postural) hypotension Tongue angioedema
Most common drugs that cause anaphylaxis
Penicillins Muscle relaxants NSAIDs Contrast agents Latex
Drugs that can cause SJS/TEN
allopurinol carbamazepine lamotrigine phenytoin phenobarbital nevirapine -oxicams sulfa antibiotics sulfasalazine sertraline
Treat SJS-TEN with high dose steroids, IV Ig, cyclophosphamide, ciclosporin, plasma exchange. Lots of supportive care, as a burns victim.
Nephrotoxic drugs - interstitial nephritis
NSAIDs
penicillin/cephalosporins
calcineurin inhibitors (tacrolimus, cyclosporin)
Nephrotoxic - acute tubular necrosis
Contrast
lithium
gentamicin (aminoglycoside)
amphotericin
Nephrotoxic - precipitates renal artery stenosis
ACE inhibitors
Nephrotoxic - glomerular damage
gold
penicillamine
NSAIDs
TB drugs
Rifampicin - orange tears
Isoniazid - neuropathy (bc causes B6 deficiency)
Pyrazinamde -
Ethambutol - optic neuritis
all - hepatitis
Ca-channel blockers
Heart failure, arrhythmias
ankle oedema
headache/flushing/dizziness
bradycardia
[extra card just to put the website to see for more core SEs]
http://oscestop.com/Common_side_effects.pdf
