Common Conditions - Infectious Disease

Question 1

Transmission: HCV

Answer 1

Parenteral (IV drug use MC), Sex (

Question 2

What % of acute HCV infections progress to chronic HCV?

Answer 2

85%

Question 3

HCV is the leading cause of __(2).

Answer 3

chronic hepatitis, liver transplants

Question 4

What % of chronically infected HCV/HBV pts develop cirrhosis?

Answer 4

20%

Question 5

SSx: HCV/HBV

Answer 5

Jaundice, scleral icterus, hepatomegaly, fatigue, weight loss, dark urine

Question 6

Dx: HCV

Answer 6

anti-HCV abs (screen), HVC RNA quant, genotyping

Question 7

Labs: HCV/HBV

Answer 7

LFT (mixed direct/indirect hyperbillirubinemia, elev. AST/ALT), CBC (elev. WBC w/ atypical lymph), elev. PT time

Question 8

What lab finding is suggestive of alcoholic hepatitis?

Answer 8

AST:ALT >2

Question 9

Test to r/o cirrhosis

Answer 9

LV bx

Question 10

Transmission: HBV

Answer 10

Parenteral, Sex, Mom-to-fetus

Question 11

Dx: HBV

Answer 11

HBsAg = disease
Anti-HBsAg = immunity/cure
HBcAg = active infection
IgM anti-HBcAg = new infx
IgG anti-HBcAg = old infx
HBeAg = high infectivity
Anti-HBeAg = low infectivity

Question 12

HBV is more severe when there is a ___.

Answer 12

HDV co-infection

Question 13

What % of adults infected with HBV develop chronic HBV?

Answer 13

5% (80-90% if <1 yr, 30-50% if <6 yr)

Question 14

Transmission: HAV

Answer 14

Fecal-oral

Question 15

SSx: HAV

Answer 15

acute, mb asx, mild acute hepatitis

Question 16

Dx: HAV

Answer 16

Anti-HAV IgM = active infx

Anti-HAV IgG = past infx