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Cancer Genetics > Common cancers > Flashcards

Common cancers Flashcards

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1
Q

Breast cancer

A 
BRCA1 (triple -, medullary)
BRCA2 (triple -)
TP53 (triple +)
PTEN
CDH1 (lobular)
CHEK2
ATM
PALB2 (triple -)
STK11 (infiltrating ductal and papillary)
NF1
NBN
Bloom syndrome
Werner syndrome
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2
Q

Ovarian cancer

A

BRCA1 (Papillary serous cystadenocarcinoma)
BRCA2 (Papillary serous cystadenocarcinoma)
RAD51C
RAD51D
BRIP1
Lynch (endometrioid/ clear cell)
STK11 (mostly SCTAT)

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3
Q

Prostate cancer

A 
BRCA2
BRCA1
CHEK2
Lynch
ATM
NBN
BRIP1
HOXB13
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4
Q

Pancreatic cancer

A 
BRCA2 (>BRCA1)
PALB2
Lynch
APC (low risk)
STK11
ATM
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5
Q

Skin cancer

A 
BRCA2
PTEN
RB1
Bloom syndrome
Gorlin syndrome (BCC)
Xeroderma pigmentosum
Birt Hogg Dube (melanoma)
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6
Q

Colorectal cancer / polyps

A 
MLH1, MSH2, MSH6, PMS2 (Lynch; adenocarcinoma)
APC (FAP)
MUTYH (autosomal recessive)
PTEN
STK11 (PJS)
MSH3 (autosomal recessive)
Bloom syndrome
SMAD4 and BMPR1A (Juvenile polyposis syndrome)
POLE
POLD1
Constitutional mismatch repair deficiency (CMMRD) syndrome
NTHL1
RNF43
GREM1
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7
Q

Thyroid cancer

A

PTEN (follicular&raquo_space; papillary, never medullary)
APC (cribriform-morular variant of papillary)
Hereditary Paraganglioma-Pheochromocytoma Syndromes (papillary)
RET (causing MEN2; medullary)
DICER1 (differentiated)

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8
Q

Endometrial cancer

A

PTEN
Lynch
POLD1

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9
Q

Renal cancer

A
  • PTEN (papillary)
  • Hereditary Paraganglioma-Pheochromocytoma Syndromes (clear cell)
  • VHL (clear cell)
  • Hereditary leiomyomatosis and renal cell cancer (papillary type 2)
  • BHD (chromophobe or oncocytic)
  • TSC [epithelial (various) or mesenchymal (angiomyo-lipoma)]
  • Hereditary papillary renal cell carcinoma
  • Rhabdoid tumor predisposition syndrome
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10
Q

Gastric cancer

A 
Lynch (intestinal-type adenocarcinoma)
CDH1
APC
MSH3
STK11 / PJS
TP53
Carney complex
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11
Q

Brain cancer

A 
Gorlin (medulloblastoma)
Lynch (glioblastoma)
APC (medulloblastoma)
RB1 (PNET)
TSC
NF1
Bloom
NF2
Constitutional mismatch repair deficiency (CMMRD) syndrome
PTEN
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12
Q

Lung cancer

A

STK11
TP53 (bronchoalveolar)
DICER1 (pleuropulmonary blastoma)

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13
Q

Leukemia / lymphoma

A 
TP53
Trisomy 21
RASopathies
Fanconi anemia
Bloom syndrome
ATM
Dyskeratosis congenita
Diamond-Blackfan anemia
Shwachman-Diamond
NF1
Constitutional mismatch repair deficiency (CMMRD) syndrome
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Cancer Genetics (4 decks)

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