Common Alimentary Drugs Flashcards
What is Sulcralfate? What is it’s use?
Sulcralfate is used to regulate acid secretion, used as a protective barrier in oesophageal disease and gastric ulceration.
What is the mechanism of Sulcralfate? What dose would you give?
It reacts with HCl to form a sticky substance that binds exudate at ulcer sites. 20kg: 1mg/dog q6-8 hours.
What is Omeprazole? What is it’s use?
Used to regulate acid secreition, used in gastric hyper-acidity, GI ulcers and erosion.
What is the mechanism of Omeprazole? What dose would you give?
Proton pump inhibitor, so decreases pH in stomach. Long duration so given daily.
What are Cimetidine/Ranitidine/Famotidine? What is their use?
Used to regulate acid secreition by antagonising H2 receptor. Used in vomiting regurgitation. There is no evidence for efficacy in cats and dogs!
What is Metclopramide? What is it’s use? What is it’s mechanism?
It is an anti-emetic, used to treat vomiting. PABA derivative which has central and peripheral action. Antagonises dopamine and serotonin.
What dose of Metclopramide would you give?
0.2-0.5mg/kg. Tablet, suspension or injection.
What is Ondansetron? What is it’s use? What is it’s mechanism?
Anti-emetic used to treat vomiting and nausea. Quite often used in pancreatitis. Serotonergic antagonist that acts centrally.
What dose of Ondansetron would you give? Why might you not use Ondansetron?
0.5mg/kg IV or 0.5-1mg/kg PO q12-14 hours. It is expensive.
What is Maropitant? What is it’s use? What is it’s mechanism?
Anti-emetic used to treat vomiting that has both central and peripheral effects. VERY POTENT. Neurokinin-1 antagonist.
What dose of Maropitant would you give?
Dogs: 1mg/kg SC, 2mg/kg PO
