Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Oncology > Colorectal Cancer Drugs > Flashcards

Colorectal Cancer Drugs Flashcards

1
Q

What’s been the mainstay of treatment for 50years

A

5-fluorouracil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rationale for giving folinic acid with 5-FU

A

Folinic acid increases and prolongs inhibition of TS therefore increases efficacy of 5-FU and clinical outcome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Side effects of 5-FU

A 
Diarrhoea 
Stomatitis 
N&V 
Bone marrow suppression 
Hand-foot syndrome 
Excessive tear shedding
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What’s in the oxaliplatin de gramont for dukes C colorectal cancer

A

5-fluorouracil
Oxaliplatin
Folinic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA of oxaliplatin

A

Cross links DNA preventing replication and cell division

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Benefit of oxaliplatin over cisplatin

A

Less nephrotoxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Side effects of oxaliplatin

A

Peripheral neuropathy
Acute pharyngolaryngeal dysasthesis
Bone marrow suppression
Mild alopecia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Why do you need a slow infusion of chemo in colorectal cancer

A

Tumour cells have a low growth potential and 5-FU is only active in S phase and short T1/2 10mins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What’s capecitabine

A

Prodrug of 5-FU given orally (3 step activation, 2 of which in tumour cells)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Side effects of capecitabine

A

Diarrhoea
Hand and foot syndrome
Nausea and vomiting
Stomatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA irinotecan

A

Topoisomerase 1 inhibitor (enzyme that unwinds DNA during replication)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of trifluridine-tipiracil

A

Trifluridine is a thymidine analogue, gets phosphorylated and metabolised to a DNA substrate that’s taken up into DNA preventing cell proliferation
Tipiracil is an inhibitor of TPase (enzyme that degrades trifluridine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When would you use lonsurf (trifluridine-tipiracil)

A

Metastatic colorectal cancer (usually after other therapies)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Side effects of lonsurf (trifluridine- tipiracil)

A 
N&V
Diarrhoea 
Sore mouth 
Taste change 
Bone marrow suppression 
Anaemia 
Bleeding 
Hand-foot syndrome 
Alopecia 
Tiredness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of bevacizumab

A

Binds VEGFA Ligand preventing binding to VEGF receptor preventing angiogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Place in therapy of bevacizumab

A

Metastatic colorectal cancer after 1st line chemo used in combo with non-oxaliplatin chemo

17
Q

Side effects of bevacizumab

A 
Osteonecrosis of jaw
GI perforation 
CHF 
Haemorrhage 
Hypertension 
Proteinuria 
Diarrhoea 
Vomiting 
Abdominal pain
18
Q

MOA of cetuximab

A

Chimeric monoclonal igG1 antibody that binds EGFR blocking its action, internalisation of receptor and antibody dependent cell mediated cytotoxicity

19
Q

Side effects of cetuximab

A 
Acne 
Meningitis 
Blepharitis 
Conjunctivitis 
Chills 
Diarrhoea 
Vomiting
20
Q

Place in therapy

A

EGFR+ RAS WT metastatic colorectal cancer

Oncology (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions