COLORECTAL CA Flashcards
1
Q
mucosa at risk
A
methylation abnormalities
inactivation of normal alleles
2nd hit
APC,BETA CATENIN
2
Q
normal colon
A
germline/somatic muration of cancer suppresor gene(1st hit)
APC at 5q21
3
Q
adenomas
A
protooncogene mutations
KRAS at12p12
homozygous loss of additional cancer suppresor genes
overexpression of COX-2
TP53 at 17p13
LOH at 18p21
(SMAD 2 & 4)
4
Q
ca
A
additional mutations
gross chromosomal alterations
Telomerase,other cancer genes
5
Q
MSI
A
DEFECT IN DNA MISMATCH REPAIR
