Collagen Flashcards
what is the most abundant protein in the human body
collagen
what are the most common types of collagen and what does collagen do
I and IV
it organizes and strengthens the extracellular matrix
what is the mnemonic for collagen types
SCAB
Skeleton- 1
Cartilage- 2
Arteries- 3
Basement membrane- 4
type 1 collagen is located where?
it is located in the bone, skin, tendon, dentin, fascia
late wound repair
Type I: bONE, tendONE
Type 1 collagen has decreased production in what disorder?
osteogenesis imperfecta type I
type II collagen is located where?
cartilage, vitreous body, nucleus pulposus
type II: cartwolage
type III collagen is where
blood vessels, skinm uterus, fetal tissue, early wound repair
type III collagen in deficient in what disorder?
vascular type of ehlers danlos syndrome
type IV collagen is located where
in the basement membrane/basal lamina (glomerulus, cochlea), lens
type IV collagen is defective in what disorders
alport syndrome
goodpastures syndrome (attacked by antibodies)
_ are responsible for secretion and wound contraction
myofibroblasts
what collagen works during early wound repair
late wound repair?
early: collagen type 3
late: collagen type 1
explain the synthesis of collagen
Preprocollagen: GLY-X-Y (1/3 glycine)
HydroClation: of proline and lysine residues that requires vitamin C
Glycosylation: of alpha chain and forms Procollagen with disulfide bonds to create a triple helix
Exocytosis: procollagen goes into the extracellular space
Proteolytic processing: form tropocollagen by cleaving disulfide rich regions of procollagen
Assembly: tropocollagen and aligns for crosslinking
Cross Linking: tropocollagen staggering with hydroxylysine crosslinking to make fibrils
a defect in the hydroxylation step leads to what
vitamin C def because vitamin C is required for hydroxylation scurvy will result
defect in the glycosylation step results in
not being able to form a triple helix of collage a chains and osteogenesis imperfecta
