Cognitive Neuroscience Flashcards
What is one of the hallmarks of human behaviour, differentiating it from that of animals?
- animals’ behaviour is reflexive while humans’ behaviour is goal-driven, adaptive and context dependent
What happened to Phineas Gage and how did it affect his behaviour?
- A tamping pole impaled his skull and took out a portion of the frontal part of his brian
- his personality changed - became rude, fitful, impatient, and unable to execute pre-planned behaviours
What is the Wisconsin Card Sorting Task (WCST)?
a task involving cards with different properties (shape, colour, number,)
ps had to sort the card by one relevant property
they have to figure out the relevant property using the feedback (correct/incorrect)
then the property changes and they have to figure it out again
What skills does the WCST involve?
learning rules, task switching, inhibition (of previous rules)
What is are the recency and self-ordered pointing tasks?
Recency - presented images and have to state which one appeared most recently
Self-ordered pointing - have 8/some images on a page and have to point at each of them in whatever order without going back on yourself
What did Milner/Milner and Petrides conclude from the WCST, recency task and self-ordered pointing task?
that ps with frontal resections had problems with recency judgements, planning, self-generated action, and made preservation errors
In what area do lesions lead to normal performance in lab tasks but serious issues in the real world? Which case-study provides evidence of this?
the ventromedial prefrontal cortex
Case study: EVR (Eslinger and Damasio, 1985)
What were EVR’s symptoms?
- normal on cognitive tests e.g. WCST and recency/freq judgements
- able to comment with wit on daily events
- poor financial decisions
- consumed in deliberation over inconsequential things
What are imitation and utilisation behaviours and who studied them?
imitation: voluntarily imitating behaviours of experimenter despite not being asked to and after being asked to stop
precedes utilisation behaviour
utilisation: kinda like affordances, excessive reliance on cues from the environment
Lhermitte studied them (1985)
What are the functions of executive control? (5)
planning goal setting task switching conflict monitoring and resolving response inhibition
What are the 2 functions that can be considered as part of executive control, but can also be considered separately?
working memory
attention
What is the Tower of London task? What executive function does it test? What is its non-lab-based equivalent?
A task where you are given a set of objects in a particular configuration and are given a desired endstate
have to get it from initial state to end state
tests planning
multiple-errands - given a list of tasks to do e.g. getting items for a shop with a budget, gathering information etc
What task did Jersild formulate, how does it work, and what executive function does it test?
Mental set and shift task
Number/letter combination presented
had to classify as odd/even or vowel/consonant
task changed every 2 trials and cued by location of combination
on switch trials, response time was much higher
tests task switching
What is the Stroop task and what executive function does it test?
Colour naming task
Have to name colours as colour blocks or as words describing other colours
slower to name words describing colours than colour blocks
tests conflict monitoring and resolution
what is the stop-signal task and what function does it test?
a task in which participants are presented with a fixation signal and then presented with a go signal/a go signal followed by a stop signal and then either inhibit their response, or continue as it is too late to stop
tests reponse inhibition
What is the Supervisory Attention System and who was it devised by?
Theory of how executive function guides behaviour
states that our behaviour runs automatically through schemas most of the time but control functions interfere in special situations
Normal and Shallice
What are the three levels of performance in the Supervisory Attention System and how do they work?
Automatic - normal functioning, happening most of the time using motor schemas
Contention Scheduling - selects from competing action schemas
Deliberate Conscious Control - biases selection process of previous system when actions are: ill-learned, novel, critical, dangerous or require planning
In which situations does the Supervisory Attention System dictate behaviour?
When... - action is ill-learned - situations are difficult/dangerous - to overcome habits/temptation - during planning/decision making/ troubleshooting - novel situations
In which situations does the Supervisory Attention System dictate behaviour?
When... - action is ill-learned - situations are difficult/dangerous - to overcome habits/temptation - during planning/decision making/ troubleshooting - novel situations
Explain the model suggested by Miller and Cohen?
a model of executive control in which top-down, control-related biasing signals enable temporary networks of associations based on task context between sensory inputs, internal states and response outputs
What do Braem and Egnar suggest should be taken into more consideration?
Increased links between control mechanisms and other, more primal learning mechanisms such as reinforcement learning in an integrated network
control mechanisms modified by sensory/motor signals + contingencies in the task
What areas are involved in the multiple-demand system put forward by Duncan?
- pre-supplementary motor area (SMA)
- anterior cingulate cortex (ACC)
- inferor frontal sulcus (IFS)
- intraparietal sulcus (IPS)
- rostral prefrontal cortex (rPFC)
- AI/FO
How did Duncan suggest that the multiple-demand system wprks?
a common engagement of a core network of areas in executive function
a core set of regions that are important in breaking down a task/problem into constituent pieces and planning action
does something fundamental; implicated in many EF tasks
What is the premise of hierarchical control models?
a cascade of control functions based on increasingly abstract information
caudal to rostral (back to front) organisation of the PFC - gets more abstract as you go forward
What is Rushworth et al’s approach to mapping executive function?
mapping the connections between the PFC and other functionally specialised areas of primate brains in an attempt to understand which areas are associated with which capabilities
trying to find analogies with humans
What sources of information inform perception?
Sensation
Memory
What is the nature of perception?
Limited, adaptive, focused
takes in a fraction of what happens in the environment
What are the limits of perception and what evidence do we have for them?
Change blindness (Skoda advert) Inattentional blindness (extended gorilla demo)
What are the real-life implications of these perceptual limitations?
Greig, Higham and Nobre study (2014)
similar to gorilla video but done in an ER with resuscitation paradigm
changed certain features - some were negligible, some were instrumental to patient’s survival
tested novices, doctors, and people who train on resuscitation
What are the benefits of our attention system?
Ability to identify and recognise complex patterns according to task goals
What are the better reasons for our limited perception capacity?
- Concurrent processing in networks
- Distributed processing in assemblies
- Competitive processing in neurons
- Requires selection and integration
How do concurrent processing and functional specialisation explain our limited perception?
Makes it difficult to put objects back together in the right way in their correct context (binding problem)
What are the main properties that William James assigns to attention?
- a process
- about prioritisation and selection
- 1 item chosen
- operates on internal mental landscape
- involves focusing and inhibiting
- for guiding adaptive behaviour
- essential for healthy cognition
- proactive
What is the contemporary definition of attention?
psychological and neural functions for prioritisation and selection of information to guide adaptive behaviour (based on task goals/evolutionary prompts)
What does the contemporary definition of attention mean in practice?
It means attention can be measured by measuring the difference in processing of an item depending on its importanc/relevance
What are the properties of the standard neural model of attention?
Focuses on…
- visual modality, assuming that principles generalise to others
- modulation of sensory processing based on receptive field properties (spatial and object-related features)
- top-down signals in STM
In what ways is attention broader than the standard model?
top-down signals originate from many time-scales incl. LTM
modulation isn’t just done by RF properties, also based on temporal expectations/higher order attributes e.g. meaning/social constructs
prioritisation and information selection also happens in the memory scape
What did Helmholtz’ spatial orientation task show?
The limits of perception and that we can focus at will to items across space to enhance perceptual pick up even without eyeball movements
What task did Triesman develop and what did she suggest based on it?
Visual search task
suggested that feature integration was a stumbling block
spatial attention becomes necessary to bind features into object-defining conjunctions
What task did Posner develop and what did it aim to understand?
visual-spatial orienting task
investigate how we move attention to spatial locations according to endogenous (internal, controlled, voluntary) and exogenous (involuntary, automatic) factors
What have early theoretical dichotomies surrounding attention developed into?
Theoretical pluralities
attentional modulation can happen at many processing stages, not just early or late
attentional modulation can be based on different attributes e.g. locations, objects, features within objects and locations, temporal intervals, associations and higher-order constructs
What were the early ideas about neural control of attention?
‘orienting’ ourselves towards stimuli
Descartes - voluntary orienting by shifting pineal gland
Pavlov and Sokolov - involuntary orienting response toward inherently salient stimuli, sensory receptors are positioned towards stimulus
mediated by increased cortical excitability in brainstem
What do we know about hemispatial neglect?
Lack of awareness for sensory events located towards the contralesional side of space and a loss of orienting behaviours, exploratory search etc
not a perceptual deficit - they can see, just don’t pay attention
object-based representations also matter (won’t acknowledge the left side of objects even if they do the left side of the page)
What are the cortical epicenters assocated with orienting attention?
Parietal - representation
Frontal - exploration
Cingulate - motivation (apathy/reward related signals)
Why might the TPJ (temporoparietal junction) be so important in regulating attention?
Because the white matter connections for a lot of the areas associated with this network are located there
What cortical areas are associated with attention?
Dorsal frontoparietal network Frontal eye fields post-central gyrus striatum pulvinar cingulate cortex
What other networks is the attention network similar to?
the one for controlling eye movements
What area of the brain suggests a similarity between eye movements and orienting attention?
Lateral Intraparietal Sulcus (LIP) - important for eye movements
LIP neurons show modulation according to task relevance, can have memory and motor related activity orienting attention is similar to orienting eye movements
What did Buschman and Miller (2007) find and what does it suggest?
when sensory information drives selection, LIP becomes sensitive first and then frontal areas
when memory drives selection, dorsolateral PFC becomes sensitive first
suggests that dynamics of attentional control are flexible
What do microstimulation studies show?
that stimulation of FEF and then recording from cells in V4 showed that there is a change in firing rate in V4
What can oscillations tell us about top-down control and coordination?
changes in oscillations can change which neuronal populations talk to each other and which features are integrated
if you record LFPs (local field potentials) along with firing rates there seems to be a pattern of oscillation with a frequency
if a number of regions are oscillating at the same frequency, activity in those regions will be changing at the same time
top down regions can exercise control in this way
What is the biased competition model?
suggests that competitive interactions between objects (or features) for neuronal outputs is biased through both bottom up and top down mechanisms
attention guides the integration of objects in a self-reinforcing way, overcoming binding problem
What do ERPs suggest about attention?
the same stimulus in the same location can elicit a different response based on relevance
attention is active early on and can be modulated
difficult to measure information in V1
What do brain imaging studies tell us?
modulation of visual processing in multiple areas including V1
although we can see modulation at early stages, that doesn’t mean that it starts in V1 because fMRIs have a lag, could be due to later feedback
what do primate studies reveal?
single cell recordings in primates reveal show that features from irrelevant items are filtered out of receptive fields V2, V4, IT but V1 RFs are too small to record from
what are the patterns in high-frequenct oscillation?
lot more high frequency oscillation when attending information than when not
spikes coincide with troughs which causes synchronisation and creates a burst which prioritises a signal
what evidence is there for top-down control of attention in ERPs?
Chelazzi et al.
neurons that were attuned to a particular stimulus showed elevated baseline activity during the anticipatory period
could provide evidence for top-down activation which provides a competitive advantage to coding of these locations/objects
what has multivoxel pattern analysis shown about attentional control in humans?
pre-activation of stimulus representations during anticipatory attention
attention can lead to pre-activation of the same neuronal assemblies that code for perception of the same stimuli
What have we learnt about temporal expectations and attention?
they can modulate activity in STM to guide adaptive behaviour
How did Hebb suggest that long and short term memory could be supported in the brain?
STM - reverberation in cell assemblies
LTM - synaptic plasticity
What did Sperling (1960) find about the capacity of iconic memory and STM?
Increased input led to increased memory until 4 items after which it plateaued
What did Sperling find out about the effect of cues?
When people were cued to information in a particular row, their recall was much better
this was mediated by the time when the cue was delivered
when the cue was immediate, recall was almost 100%
when the cue was a second later, performance was as bad as if there hadn’t been a cue
What is iconic memory and what is the difference between that and STM?
Iconic memory - the visual version of echoic memory, the immediate retention of things in the visual field, before you’re even cognitively aware of them
What did Peterson and Peterson conclude from their study about decay in STM?
The longer the gap between stimulus presentation and recall, the more likely the STM is to decay
In which two ways can the serial position curve/effect interpreted?
- LTM vs STM - first items in the list are retained as they’ve moved into LTM (primacy), last ones are retained because they’re still in STM (recency)
- first items protected as they aren’t affected by proactive interference, last items are protected as they aren’t affected by retroactive interference
What did Milner show in her study of HM? What more evidence was needed?
That STM memory and retention of information could be preserved even if LTM was gone
A double dissociation - evidence that LTM could be spared while STM was gone
How was a double dissoction established by Shallice and Warrington?
What were its limitations?
Case study of KF - had ‘normal’ LTM but limited STM
The STM and LTM tasks that they used to establish the dissociation were very different
What was the distinction that Atkinson and Shiffrin made between STM and LTM?
STM is a temporary activation of LTM
doesn’t have to be in a different area of the brain, can be the same area but functions differently depending on context/activation
What did Baddeley and Hitch borrow for their Working Memory Model?
they borrowed the Supervisory Attention System to explain the action of the Central Executive
What is the purpose of the Episodic Buffer?
To store and compartmentalise memories into episodes so that we have a cohesive experience
Limited capacity store
What did precision tasks aim to ascertain and what did they find?
whether people are actually retrieving things or whether they are just guessing
the more information people are presented with, the more they guess
concluded that people weren’t completely guessing, information was eroding and could be broken down into slots
What is the relationship between attention and memory?
memory provides information and attention selects and prioritises to guide adaptive behaviour
How can research into delay cells tell us more about Hebb’s theory of reverberation in cell assemblies?
Some cells aren’t active in response to a stimulus, but are active during the delay before recall
maybe this sustained firing is a pneumonic trace
could be representing the stimulus/controlling its representation elsewhere
What is the evidence against delay activity’s importance in memory?
studies have found it isn’t necessary for memory in animals
activity related to encoding can be kept, inactive in the mind and then be reactivated when needed (Watanabe and Funahashi)