cognitive disorders Flashcards
delirium: general
- waxing-and-waning change in level of consciousness
- caused by almost any medical d/o
- high morbidity and mortality if untreated
delirium: epidem
- 10-30% of admitted medical pts
- common in elderly, ICU, postop, cancer pts
delirium: risk factors
- adv age
- brain damage
- prior delirium
- alcohol dependence
- cancer
- sensory impairment, blindness
- malnutrition
- male gender
delirium: clinical
MOST common: impairment in recent memory
- disorientation, usually to time/place
- language disturbances, speech changes
- perceptual disturbances, esp visual hallucinations
- sleep disturbances: SUNDOWNING (daytime drowsiness and night-time insomnia)
- disturbed psychomotor behavior
- emotional disturbances
- perseveration
delirium: dx
- disturbance of consciousness w/reduced ability to focus, sustain, shift attn
- change in cognition or development of perceptual disturbance (can’t be accounted for by dementia)
- disturbance develops over short period of tie and fluctuates
delirium: tx
- r/o life-threatening cause, find underlying condition
- hydration, nutrition
- 1:1, orient patient, good sleep hygiene
- Haldol for agitation
- BZOs only for DTs
dementia: general
- impairment of memory and other cognitive fns WITHOUT altered consciousness
- most forms progressive, irreversible
- prevalence doubles every 5 years: 1.5% at 60 yrs, 40% at 90 yrs
- Alzheimer’s most common, vascular dementia 2nd
dementia: dx
- multiple cognitive deficits manifested by BOTH: memory impairment and 1+ of: aphasia, apraxia, agnosia, decreased executive fn
- cognitive deficits must cause significant impairment and are significant decline
- do not occur only during delirium
dementia: assoc sx
- delusions and hallucinations: 30%
- affective sx: 40-50%
- personality changes
dementia: reversible causes
- workup CBC, electrolytes, TFTs, VDRL/RPR, B12/folate, brain CT/MRI
- hypothyroidism
Alzheimer: epidem
- most common type of dementia
- women 3x > men
- 1st degree relative –> 4x risk
- Down syndrome –> increased risk
Alzheimer: clinical
- gradual progressive decline in cognitive fn
- personality chg, mood swings, paranoia common
- motor and sensory sx absent until late in cours
Alzheimer: dx
- clinical, dx of exclusion unless post-mortem
- genes: only 5% of cases; APOe4 gene –> homozygotes have 50-90% chance, heterozygotes 45% chance
- 20% chance overall
- postmortem: diffuse atrophy with enlarged ventricles, flattened sulci
- senile plaques and NF tangles
Alzheimer: pathophys
- decrease in ACh - loss of noradrenergic neurons in basal ceruleus and decreased choline acetyltransferase
- excess of Abeta peptides (overprod, decreased clearance)
Alzheimer: tx
- cholinesterase inhibs for mild-mod dz
- tacrine, donepezil, rivastigmine, galantamine
- NMDA antagonists for mod-severe dz
- memantine
vascular dementia: general
- 2nd most common form
- microvascular dz in brain –> multiple small infarcts
- risk factors: stroke, DM, HTN, APOe4, male (2x>women)
vascular dementia: clinical
- STEP-WISE deterioration
- lateralizing signs
- depression, anger, paranoia common
- frontal lobe stroke –> SCZ/BiPD/depressive sx
vascular dementia: tx
- cholinesterase inhibitors
- antiHTN tx to prevent onset (?)
- symptomatic tx
lewy body dementia: pathophys
- lewy bodies and lewy neurites = pathologic aggregations of alpha synuclein in brain
- mostly in basal ganglia
lewy body dementia: clinical
- WAXING AND WANING cognition
- visual hallucinations: animals or people, colorful
- paranoid delusions
- parkinsonism
- SENSITIVITY TO NEUROLEPTICS
- REM sleep behavior do
lewy body dementia: dx
- onset of dementia w.in 12 mos of parkinsonism sx
lewy body dementia: tx
- cholinesterase inhibs (help with VH)
- psychostimulants, levodopa/carbidopa, DA agonists
- atypical neuroleptics
- clonazepam for REM do
frontotemporal dementia
- diverse group of dos
- present bw ages 45-65
- approx 20-30% familial - progranulin or MAPT gene
- 4-6 years from illness to death
FTD: clinical
- profound chg in personality and social conduct
- disinhibition
- echolalia, overeating, oral fixation
- lack emotional warmth, insight
- cognitive deficits in attn, executive fn
- memory, language, spatial functions PRESERVED
FTD: pathophys
- marked atrophy of frontal and temporal lobes
- neuronal loss, microvacuolization, astrocytic gliosis in cortical layer II
FTD: tx
- anticholinergics, antidepressants - for behavioral sx only
HIV assoc dementia
- caused by neutropenia–>infx and direct viral effects
- risk factors: duration of HIV, low CD4, high VL
- clinical: rapid decline in cognition, behavior, motor; poor memory and concentration, apathy and social w/d, depression
- language PRESERVED
HIV assoc dementia: tx
- HAART
- psychostimulants for fatigue and psychomotor retardation
huntington dz: clinical
- onset 35-50 yrs
- progressive dementia beginning 1 year before/after chorea
- choreiform movements
- muscle hypertonicity
- depression, psychosis, alcoholism
- INCREASED SUICIDE RATE
huntington: dx
- MRI: caudate atrophy, sometimes cortical atrophy
- genetic testing (CAG repeat expansion, chrom 4)
parkinson dz: pathophys
- substantia nigra DA neuronal loss –> loss of DA provision to BG
- senile plaques and NF tangles, loss of choline acetyltransferase
- causes: idiopathic, traumatic, drugs, toxins, encephalitic, familial
parkinson dz: epidem
- 30-40% develp dementia
- 50% have depression
- men > women
parkinson: clinical
- similar to Alzheimer
- dementia rarely initial sx
- parkinsonism
- dementia EXACERBATED by antipsychotics
creutzfeld jakob dz: general
- rapidly progressive, degenerative CNS dz
- prion accumulation
- older patients
- small percentage infected via corneal transplants
CJD: clinical
- rapidly progressive dementia 6-12 mos after sx onset
- > 90% : MYOCLONUS
- BG and cerebellar dysfn common
- early sx: personality chg, immature behavior, paranoia
- rapid progression to stupor/coma/death
CJD: dx
- pathological: spongiform chg in brain tissue
- periodic generalized sharp waves on EEG
- 2+: myoclonus, cortical blindness, ataxia, pyramidal/EPS, muscle atrophy, mutism
normal pressure hydrocephalus
- potentially reversible cause of dementia
- enlarged ventricles, increased CSF pressure
- cause: idiopathic or 2/2 CSF obstruction
- Wobbly (gait disturbance), Wet (urinary incontinence), Wacky (dementia)
- tx: shunt
- dementia least likely to improve