Cognition, dementia, end-of-life care, and death & dying Flashcards
What are Amyloid plaques and tau tangles more prevalent in?
Individuals with dementia
What happens as we age to your brains?
Decreased gray and white matter structure & volume
Especially in frontal lobe
Decreased dopamine concentration, transported availability, and receptor density
Aging brain more susceptible to pathology
Synapses age
What aspects of memory remain relatively stable with age?
Some aspects of memory (especially implicit memory), language, and social cognition remain relatively stable with age
What types of cognitive processes show gradual and declines?
Processing speed, encoding of information into episodic memory, short-term memory, and executive function show gradual and linear declines with aging
What are some typical normal cognitive aging features?
Need increased time for processing
Require more rehearsal to encode information into long-term memory
Have decreased ability to multi-task
Have difficulty with problem-solving
True or false,Some older adults will exhibit no observable slowing of cognition, while others may display noticeable changes that are considered “within normal limits”
True
What is delirium?
Abrupt change in mental status and behavior with impairment in cognitive processes and attention deficits2
Clinical syndrome characterized by disturbed consciousness, cognitive function impairment, and perception1
What is link to delirium?
Linked to increased LOS, morbidity, mortality, discharge to SNF, re-admission1
What group of people are at higher risk of delirium?
Hospitalized older adults are at increased risk, especially in ICU settings
What is dementia?
A clinical syndrome of cognitive and functional decline
Usually chronic or progressive
What are some common subtypes of dementia?
Alzheimer dementia (41%)
Vascular dementia (32%)
Dementia with Lewy bodies (8%)
Frontotemporal dementia (3%)
How do you distinguish delirium from dementia?
What is sundowning?
Syndrome characterized by restlessness, excitement, increased confusion, hallucinations, agitation
Can occur in patients with AD or other types of dementia
Seen in late afternoon or early evening
What is mild cognitive impairment (MCI)?
Still able to carry out normal daily functions & do not experience personality changes
People with MCI have more memory problems than what is considered normal for others of the same age, but symptoms are not as severe as those with Alzheimer’s
A mild neuro-cognitive disorder
Prevalence in individuals 65+ is 15-20%
What are some common signs of MCI?
Losing things
Forgetting appointments
Trouble with word-finding
Forgetting conversations
May be easily distracted
Difficulty managing finances or medications
What is Alzheimer’s disease?
Alzheimer disease: brain disease characterized by amyloid plaques, neurofibrillary tangles, and neuronal loss;4 leading cause of dementia in late adult life2
What is Alzheimer’s dementia?
Alzheimer dementia: a dementia syndrome that has gradual onset and slow progression, best explained as caused by Alzheimer disease 4
What is vascular dementia?
Cognitive impairment with the essential feature of underlying cardiovascular disease, usually in a step-wide decline
Cerebrovascular disease, typically in the form of vascular strokes, results in ischemic brain damage and cognitive loss
What are some characteristics of vascular dementia?
What is dementia with Lewy bodies?
Progressive cognitive decline sufficient to interfere with daily function caused by build-up of Lewy bodies inside neurons
Accumulated bits of alpha-synuclein protein
Similar symptoms to AD, but more likely to have early symptoms of sleep disturbances, visual hallucinations, slowed gait speed with imbalances, and parkinsonian movement features (tremor, rigidity, bradykinesia)
Symptoms may occur without significant memory impairment
What is frontotemporal dementia?
Group of dementias caused by progressive nerve cell loss in the frontal or temporal lobes, resulting in atrophy
Causes changes in behavior and personality, language disturbances, and alterations in muscle/motor function
Impairment of executive function and more difficulty with problem solving than patients with AD
Relatively preserved memory and spatial organization compared to those with AD
Cortical microvasculature changes and loss of synapses at the microscopic level
Insidious onset between age 45 – 70, with estimated duration 3 – 17 years
What is geriatric failure to thrive?
A multi-factorial state of decline in vitality that may be caused by chronic concurrent disease and functional impairment
Not a normal consequence of aging, not synonymous with dementia, not a descriptor of later stages of a terminal illness
What should a diagnoses of failure to thrive prompt?
End-of-life questions/options
What is geriatric failure to thrive associated with?
increased healthcare costs, as well as increased morbidity and mortality