Coenzymes Flashcards
what is the vitamin source of adenosine triphosphate (ATP)?
None
what is the metabolic role of adenosine triphosphate (ATP)?
transfer of phosphoryl or nucleotidyl groups
what is the mechanistic role of adenosine triphosphate (ATP)?
cosubstrate
what is the vitamin source of S-adenosylmethionine (SAM)?
None
what is the metabolic role of S-adenosylmethionine (SAM)?
transfer of methyl groups
what the mechanistic role of S-adenosylmethionine (SAM)?
cosubstrate
what is the vitamin source of uridine disphosphate glucose?
none
what is the metabolic role of uridine disphosphate glucose?
transfer of glycosyl groups
what is the mechanistic role of uridine disphosphate glucose?
cosubstrate
what is the vitamin source of nicotinamide adenine dinucleotide (NAD+)/nicotinamide adenine dinucleotide phosphate (NADP+)?
Niacin (B3)
what is the metabolic role of nicotinamide adenine dinucleotide (NAD+)/nicotinamide adenine dinucleotide phosphate (NADP+)?
oxidation-reduction reactions involving two electron transfer
what is the mechanistic role of nicotinamide adenine dinucleotide (NAD+)/nicotinamide adenine dinucleotide phosphate (NADP+)?
cosubstrate
what is the vitamin source of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)?
riboflavin (B2)
what is the metabolic role of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)?
oxidation-reduction reactions involving one- and two-electron transfers
what is the mechanistic role of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)?
prosthetic group
what is the vitamin source of coenzyme A (CoA)?
pantothenate (B5)
what is the metabolic role of coenzyme A (CoA)?
transfer of acyl groups
what is the mechanistic role of coenzyme A (CoA)?
cosubstrate
what is the vitamin source of thiamine pyrophosphate (TPP)?
thiamine (B1)
what is the metabolic role of thiamine pyrophosphate (TPP)?
transfer of multi-carbon fragments containing a carbonyl group
what is the mechanistic role of thiamine pyrophosphate (TPP)?
prosthetic group
what is the vitamin source of pyridoxal phosphate (PLP)?
pyridoxine (B6)
what is the metabolic role of pyridoxal phosphate (PLP)?
transfer of groups to and from amino acids
what is the mechanistic role of pyridoxal phosphate (PLP)?
prosthetic group
what is the vitamin source of biotin?
Biotin (B7)
what is the metabolic role of biotin?
ATP-dependent carboxylation of substrates or carboxyl-group transfer between substrates
what is the mechanistic role of biotin?
prosthetic group
what is the vitamin source of tetrahydrofolate?
folate
what is the metabolic role of tetrahydrofolate?
- transfer of one-carbon substituents, especially formyl and hydroxymethyl groups
- provides the methyl group for thymine in DNA
what is the mechanistic role of tetrahydrofolate?
cosubstrate
what is the vitamin source of cobalamin?
cobalamin (B12)
what is the metabolic role of cobalamin?
- intramolecular rearrangements
- transfer of methyl groups
what is the vitamin source of lipoamide?
none
what is the metabolic role of lipoamide?
oxidation of hydroxyalkyl group from TPP and subsequent transfer as an acyl group
what is the mechanistic role of lipoamide?
prosthetic group
what is the mechanistic role of cobalamin?
prosthethic group
what is the vitamin source of retinal?
vitamin A
what is the metabolic role of retinal?
vision
what is the mechanistic role of retinal?
prosthetic group
what is the vitamin source of vitamin K?
vitamin K
what is the metabolic role of vitamin K?
carboxylation of some glutamate residues
what is the mechanistic role of vitamin K?
prosthetic group
what is the vitamin source of ubiquinone (Q)?
none
what is the metabolic role of ubiquinone (Q)?
lipid-soluble electron carrier
what is the mechanistic role of ubiquinone (Q)?
cosubstrate
what is the vitamin source of heme group?
none
what is the metabolic role of heme group?
electron transfer
what is the mechanistic role of heme group?/
prosthetic group