Coeliac disease Flashcards
1
Q
Signs and symptoms of coeliac disease?
A
- Chronic/ intermittent diarrhoea
- Failure to thrive
- Persistent gastro symptoms with fatigue
- Recurrent abdo pain
- Unexplained iron deficiency anaemia
2
Q
Serology testing for coeliac disease?
A
Tissue transglutaminase (TTG) antibodies 1st choice (>10U/ml = coeliac)
and
Total IgA levels
second line- anti EMA
3
Q
Always test for coeliac disease in new onset of which 2 autoimmune conditions?
A
- Type 1 diabetes
- Thyroid disease
4
Q
Inflammation affects where?
A
Small bowel- jejunum
5
Q
Which 2 genotypes is coeliac disease associated with?
A
HLA-DQ2 and HLA-DQ8
6
Q
Skin issue caused by coeliac disease?
A
Dermatitis herpetiformis- itchy blistering skin rash typically on abdo
7
Q
Endoscopy findings in coeliac disease?
A
Crypt hyperplasia
villous atrophy