Cocaine

Question 1

The experiments by Soria et al. (2005) showed that CB1 knockout mice
a. self-administer cocaine and will reach higher progressive ratio breakpoints compared to
wild-type controls.
b. self-administer cocaine, but will reach lower progressive ratio breakpoints compared to
wild-type controls.
c. respond to rimonabant treatment by increasing their intake of cocaine.
d. will not self-administer cocaine.

Answer 1

b)
self-administer cocaine, but will reach lower progressive ratio breakpoints compared to wild-type controls

Question 2

Mice with cocaine insensitive dopamine transporters
a. self-administer cocaine to a greater extent than heterozygous controls
b. exhibit self-administration behavior that is indistinguishable from that observed in DAT
knock-out mice.
c. have no significant change in nucleus accumbens dopamine following cocaine injections.
d. have no significant change in dorsal raphe dopamine following amphetamine injections.

Answer 2

c)
have no significant change in cycles accumbent dopamine following cocaine injections