coagulative disorders Flashcards
is a stepwise series of enzymatic reactions that results in the formation of a fibrin mesh
coagulation cascade
coagulation cascade can be triggered through which pathways
- intrinsic
- extrinsic
is activated when negatively charged surfaces in contact with the blood activate factor XII, and activated platelets convert factor XI
intrinsic pathway
is activated when damaged vascular tissue releases tissue thromboplastin
extrinsic pathway
this also exposes the sub-endothelium, causing adherence, activation, and aggregation of platelets
vascular injury
the intrinsic and extrinsic pathways meet at a common point with the activation of _____
factor X
partner of factor Xa in converting prothrombin (II) to thrombin (IIa)
factor Va
thrombin will cleaves _____ to form fibrin monomers
fibrinogen
this covalently bonds fibrin strands together
factor XIII
the fibrinolytic protein that ultimately degrades the fibrin mesh into soluble end products known as fibrin split products or fibrin degradation products
plasmin
a medical condition in which the ability of the blood clot is severely reduced, causing the sufferer to bleed severely from even a slight injury
hemophilia
the condition is typically caused by a hereditary lack of coagulation factor of the factor VIII or factor IX
hemophilia
hemophilia other name
royal’s disease
queen victoria’s 3 children whom she passed her hemophilia B
- leopold
- alice
- beatrice
the severity of hemophilia that a person has is determined by the amount in the _____
blood
