coagulative disorders

Question 1

is a stepwise series of enzymatic reactions that results in the formation of a fibrin mesh

Answer 1

coagulation cascade

Question 2

coagulation cascade can be triggered through which pathways

Answer 2

• intrinsic
• extrinsic

Question 3

is activated when negatively charged surfaces in contact with the blood activate factor XII, and activated platelets convert factor XI

Answer 3

intrinsic pathway

Question 4

is activated when damaged vascular tissue releases tissue thromboplastin

Answer 4

extrinsic pathway

Question 5

this also exposes the sub-endothelium, causing adherence, activation, and aggregation of platelets

Answer 5

vascular injury

Question 6

the intrinsic and extrinsic pathways meet at a common point with the activation of _____

Answer 6

factor X

Question 7

partner of factor Xa in converting prothrombin (II) to thrombin (IIa)

Answer 7

factor Va

Question 8

thrombin will cleaves _____ to form fibrin monomers

Answer 8

fibrinogen

Question 9

this covalently bonds fibrin strands together

Answer 9

factor XIII

Question 10

the fibrinolytic protein that ultimately degrades the fibrin mesh into soluble end products known as fibrin split products or fibrin degradation products

Answer 10

plasmin

Question 11

a medical condition in which the ability of the blood clot is severely reduced, causing the sufferer to bleed severely from even a slight injury

Answer 11

hemophilia

Question 12

the condition is typically caused by a hereditary lack of coagulation factor of the factor VIII or factor IX

Answer 12

hemophilia

Question 13

hemophilia other name

Answer 13

royal’s disease

Question 14

queen victoria’s 3 children whom she passed her hemophilia B

Answer 14

• leopold
• alice
• beatrice

Question 15

the severity of hemophilia that a person has is determined by the amount in the _____

Answer 15

blood

Question 16

TRUE OR FALSE

lowering the factor in the blood, the more likely the bleed will occur

Answer 16

true

Question 17

TRUE OR FALSE

majority of the population experiencing
hemophilia are middle aged, elderly people, and
young women who recently give birth

Answer 17

true

Question 18

CLOTTING FACTOR

1

Answer 18

fibrinogen

Question 19

CLOTTING FACTOR

2

Answer 19

prothrombin

Question 20

CLOTTING FACTOR

3

Answer 20

tissue factor or tissue thromboplastin

Question 21

CLOTTING FACTOR

4

Answer 21

calcium

Question 22

CLOTTING FACTOR

5

Answer 22

proaccelerin, labile factor

Question 23

CLOTTING FACTOR

7

Answer 23

stable factor, proconvertin

Question 24

CLOTTING FACTOR

8

Answer 24

antihemophilic factor A

Question 25

# CLOTTING FACTOR 9