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Pharm Final 3rd Semester > CoagulationModifier Agents > Flashcards

CoagulationModifier Agents Flashcards

0
Q

Anticoagulant?

A

Heparin

LWMH (levonox, Fragmim)

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1
Q

What are the 4 categories of Coagulation Modifier agent?

A

Anticoagulant
Anti platelet
Thrombolytic agents
Hemorrherologic agents

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2
Q

Contraindications for Lwmh?

A

Stoke
Peptic Ulcer
Blood Abnormalies
Eye brain or spinal injury.

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3
Q

Anti platelets

A
  • Aspirin
  • Dipyridamole (persantine)
  • Adenosine phosphate receptor blocker (plavix, ticlopidine)
  • glycoprotein IIa/IIIb: abciximab (reopo)
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4
Q

Thrombolitics

A

Streptokinase
Urokinase
Altepase (TPA)

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5
Q

Anti platelet contraindications

A

Active bleeding
Neutropenia
Thrombocytopenia
Severe liver disease

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6
Q

Contraindications for Thrombolitics

A 
Hx of CVA within the last 2 months
Intracranial or spinal injury
Intracranial tumor or recent injury
Severe HTN
Gi bleed
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7
Q

What labs should be monitor for Heparin

A

PTT, aPTT, and platelets

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8
Q

Labs to monitor for Coumadin

A

PT and INR

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9
Q

Labs to monitor for Fragmin

A

PTT and platelets

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10
Q

Heparin black box warming

A

Epidural and spinal hematoma may result in paralysis.

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11
Q

Labs to monitor with trental (Hemorrherologic )

A

aPTT, PT, PTT, Hct and Hgb.

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12
Q

Labs to monitor in particular with streptokinase

A

ECG

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13
Q

What are sources of dietary vit K

A

Cabbage, cauliflower, spinach, green leafy vegetable

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14
Q

Oral coagulant mechanism of action

A

Inhibit hepatic synthesis of vitamin K

  • warfarin
  • Dicumarol
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15
Q

What is the INR desired value when pt is on oral anticoagulant Coumadin?

A

2-3 INR

3 =bleeding tendency

16
Q

Antidote to Coumadin

A

Vitamin K

17
Q

Antiplatelet mechanism of action

A

Prevent thrombosis by suppressing platelet aggregation

More effective with arterial thrombosis

18
Q

Clopidrogel (plavix) route and dosage

A

PO 75mg/day

19
Q

Apspirine route and dosage

A

PO, 80- 325mg/ day

20
Q

Alteplase (TPa) maximum dose and normal administration

A

Max is 100mg

Administered as IV bolus in 3 different dose and time
1st bolus then 30 min infusion and then 60 min infusion

Pharm Final 3rd Semester (3 decks)

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