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Pharm > Coagulation Meds > Flashcards

Coagulation Meds Flashcards

1
Q

Alteplase brand name?

A

Activase

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2
Q

What is Cathflo Activase?

A

Can be used to flush clogged IV or arterial lines.

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3
Q

Activase indications?

A

MI, stroke

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4
Q

What is the half-life of Alteplase?

A

5-min

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5
Q

Clopidogrel brand name?

A

Plavix

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6
Q

Most common ADP inhibitor?

A

Clopidogrel (Plavix)

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7
Q

Clopidogrel route?

A

Oral

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8
Q

Clopidogrel interactions?

A

NSAIDS
amiodarone
calcium channel blockers
PPIs

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9
Q

Clopidogrel (Plavix) category?

A

Antiplatelet

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10
Q

Alteplase category?

A

Thrombolytic

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11
Q

Aminocaproic acid brand name?

A

Amicar

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12
Q

Amicar route?

A

Oral/parenteral

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13
Q

Amicar category class?

A

Thrombolytic
(Synthetic antifibrinolytic)

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14
Q

Amicar expected action?

A

Prevent/control excessive bleeding

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15
Q

Dabigatran brand name?

A

Pradaxa

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16
Q

Dabigatran route?

A

Oral

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17
Q

Dabigatran is a prodrug that becomes activated in…?

A

The liver

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18
Q

Argatroban route?

A

IV only

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18
Q

Dabigatran adverse effects?

A

Bleeding, GI bleeding

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18
Q

Dabigatran dose is dependant on…?

A

Renal function

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18
Q

Dabigatran antidote?

A

IDARUCIZUMAB (PRAXBIND)

18
Q

Dabigatran is the first oral…?

A

Direct thrombin inhibitor

18
Q

Argatroban use?

A

Active HIT and percutaneous coronary intervention procedures in patients at risk for HIT

19
Q

Argatroban category class?

A

Synthetic direct thrombin inhibitor

20
Q

Apixaban brand name?

21
Q

Apixaban use?

A

Uncontrollable bleeding

22
Q

Apixaban category class?

A

(Anticoagulant)
Specific antidote factor XA inhibitor

23
Q

Apixaban black box warning?

A

Thromboembolic events

24
Q

Aspirin category class?

A

Antiplatelet

25
Q

Aspirin contraindications?

A

Flulike symptoms in teens and children, Reye’s syndrome

26
Q

Enoxaparin brand name?

27
Q

Enoxaparin route?

A

Injectable

28
Q

Enoxaparin category class?

A

Parenteral anticoagulant

29
Q

Enoxaparin use?

A

Prophylaxis and treatment

30
Q

Do not do this to enoxaparin.

A

Expel the air bubble in pre-filled syringes.

31
Q

Heparin can cause….?

A

Thrombocytopenia (HIT)

32
Q

Heparin category class?

A

Anticoagulant

33
Q

Heparin expected action?

A

Inhibit clotting factors II (Thrombin) and XA

34
Q

Type I HIT

A

Gradual reduction in platelets
Heparin therapy can generally be continued

35
Q

Type II HIT

A

Acute fall in the number of platelets (>50%)
Discontinue heparin therapy

36
Q

Treatment of HIT?

A

Argatroban/lepirudin

37
Q

Heparin complications?

A

Melena, hematuria, petechiae, ecchymoses, gum/mucous membrane bleeding

38
Q

Rivaroxaban brand name?

39
Q

Rivaroxaban is the first oral..?

A

Factor XA inhibitor

40
Q

Rivaroxaban use?

A

Prevention of strokes in patients with A-Fib
Post-op thromboprophylaxis Treatment of DVT and PE

41
Q

Rivaroxaban complications?

A

Dizziness, peripheral edema,
headache, bruising, diarrhea, hematuria, bleeding

42
Q

Rivaroxaban category class?

A

Anticoagulant

43
Q

Warfarin contraindications?

44
Q

Warfarin complications?

A

Skin necrosis, purple toes syndrome

45
Q

Warfarin brand name?

46
Q

Treatment for Warfarin toxicity?

A

10 mg of Vitamin K within 6 hours

47
Q

Warfarin category class?

A

Oral anticoagulant

Pharm (4 decks)

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