Coagulation/hematology Flashcards by Danielle Nies

vWF is a/n

procoagulant

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Antithrombin III is a/n

anticoagulant

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Nitric oxide is a/n

vasodilator

also inhibits plasmin binding between GPIIa/IIIb on platelets

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Thromboxane A2 is a/n

vasoconstrictor

also encourages platelet aggregation

released by activated platelet

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Plasminogen is a/n

fibrinolytic

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A-antiplasmin is a/n

antifibrinolytic

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prostacyclin is a/n

Vasodilator

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Protein C is a/n

Procoagulant

but sometimes an anticoagulant

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ADP is a/n

vasoconstrictor and platelet aggregator

released from platelet

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tPA is a/n

fibrinolytic

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Plasminogen activator inhibitor is a/n

antifibrinolytic

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Protein S is a/an:

anticoagulant and procoagulant, depending on where it is acting with thrombin in the cascade

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Fibronectin is a/n

Procoagulant

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Tissue pathway factor inhibitor is a/n

anticoagulant

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Serotonin is a/n

vasoconstrictor

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Urokinase is a/n

fibrinolytic

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thrombomodulin is a/n

procoagulant

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Factor XIII is also known as

Fibrin stabilizing factor

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Which common medications are considered to be antiplatelet

Nsaids
Pesantine
Thienpyridine (Plavix and Ticlid)

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Bleeding time

3-7 min

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12-14 seconds

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aPTT

25-32 seconds

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Thrombin time

8-12 seconds

how long it takes to form a clot after excess thrombin has been added

fibrinogen–>fibrin threads

ACT normal blood test value

80-150 seconds

activated clotting time

how long it takes to form a fibrin clot

Fibrinogen blood test normal value

>150 mg/dL

Fibrinogen degradation products normal blood value

<10 mcg/mL

D-dimer blood test normal value

<500 mg/mL

Antithrombin III blood test normal value

80%-120%

what are the primary components of FFP

all coagulation factors fibrinogen plasma proteins

What are the primary components of cryoprecipitate

fibrinogen Factor VIII factor XIII vWF

Risks of intraoperative blood salvage

Contamination Fever Hemolysis

How long do the effects of aspirin last?

8-12 days

Hold aspirin for

7 days

Hold clopidogrel for

7 days

Hold unfractionated heparin for

6 hours

hold LMWH/enoxaparin for

1-2 days

Hold warfarin for

2-4 days

Hold ticlopidine for

1-2 weeks

hold abciximab for

3 days

hold rofecoxib for

N/A

hold NSAIDS for

1-2 days

holt tPA for

1 hr

Hold streptokinase for

3 hrs

hold fondaparinux for

4 days

Hold celecoxib for

N/A

hold tirofiban for

1 days

What factors are included in PCC

II XII IX X

DDVAP is drug of choice for what 2 diseases

mild hemophilia A vWD

Most common inherited bleeeding disorder in US

vWD

most common enzymopathy

G6PD

What 2 drugs may cause cyanide toxicity in patients with G6PD?

1. Nitroprusside 2. prilocaine

What factor is commonly given for hemophilia A

Factor VIII, continue post op for 2-6 weeks

What drug can be used for mild-moderate hemophilia

DDVAP

What recombinant factor has been approved for use in hemophlia A and B

recombinant factor VII