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T IoD haemaology > Coagulation Failure > Flashcards

Coagulation Failure Flashcards

1
Q

Where are sites of bleeding in VWD/platelet disorders?

A

Skin
Mucous membranes
Epistaxis
UG and GI tract

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2
Q

where are sites of bleeding in coagulation factor deficiencies?

A

Deep in soft tissues
Joints
Muscles

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3
Q

What bleeding condition types do you get petechiae in?

A

VWD and platelet disorders

not factor deficiences

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4
Q

how do bruises vary in different types of bleeding disorders?

A

VWD/platelet disorders are small and superficial

coagulation factor deficiencies are large and deep

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5
Q

what type of bleeding deficiency do you get muscle bleeding with?

A

coagulation factor deficiencies

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6
Q

how does bleeding after cuts and scratches vary with VWD/platelet disorders compared to coagulation factor deficiencies?

A

VWD/ platelet –> bleeding

coagulation factor deficiencies –> no bleeding

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7
Q

how does bleeding after surgery or trauma vary in VWD/Platelet disorders compared with coagulation factor deficiencies?

A

Coagulation factor: severe and delayed

vwf/platelet –> mild/ moderate

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8
Q

what are the components of a blood clot?

A

Fibrin mesh
Platelets
RBC’s

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9
Q

what disorders are detected by FBC/film?

A

thrombocytopenias

Platelet dysfunctions

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10
Q

what disorders are detected by platelet dependant haemostasis?

A

VWD

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11
Q

what does PT measure pathway wise?

A

EXTRINSIC

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12
Q

what does APTT measure pathway wise?

A

INTRINSIC

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13
Q

what factor deficiencies does an abnormal PT suggest?

A

Factor VII

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14
Q

what factor deficiencies does an abnormal APTT measure?

A

FVIII, IX, XI

insignificant: FXII and contact factor

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15
Q

what factor deficiencies does an abnormal PT and APTT suggest?

A

FII, V, X

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16
Q

what abnormality does an abnormal TT suggest?

A

fibrinogen

17
Q

what are inherited bleeding disorders?

A

Haemophilia A and B

VwF deficiency

18
Q

what factor is haemophilia A?

A

8

19
Q

what factor is haemophilia B?

A

9

20
Q

what type of genetic condition is haemophilia?

A

X linked so in male population

21
Q

what is the effect of Protein C and S deficiency?

A

Increased clotting

T IoD haemaology (6 decks)

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