Coagulation Factors

Question 1

Factor I

Answer 1

Fibrinogen. Forms a clot.
synthesized in liver.
Not Vit. K dependent.

Question 2

Factor II

Answer 2

Prothrombin - when active it activates I, V, VII, XIII, platelets & protein C.
synthesized in liver.
Vit. K dep.

Question 3

Factor III

Answer 3

tissue factor or thromboplastin - a cofactor of VII.

synthesized by the vascular wall & extravascular cell membranes, released from traumatized cells.

Question 4

Factor IV

Answer 4

Calcium - promotes clotting reactions. from diet.

Question 5

Factor V

Answer 5

Proaccelerin - cofactor of X - forms a prothrombinase complex.
synthesized in liver.
not vitamin K dep.

Question 6

Factor VII

Answer 6

Proconvertin - activates IX & X. synthesized in liver.

vitamin K dep.

Question 7

Factor VIII

Answer 7

Antihemophiliac - cofactor to IX. Synthesized in liver.

NOT vitamin K dep.

Question 8

Factor IX

Answer 8

Christmas - activates X. synthesized in liver.

vitamin K dep.

Question 9

vWF

Answer 9

Von Willebrand - mediates adhesion.

synthesized in endothelial cells.

Question 10

Factor X

Answer 10

Stuart-Power - activates II forms a prothrombinase complex with V.
Synthesized in liver.
vitamin K dep.

Question 11

Factor XI

Answer 11

plasmin thromboplastin antecedent - activates IX.
liver.
vitamin K dep.

Question 12

Factor XII

Answer 12

Hageman - activates XI.
liver.
NOT vit K dep.

Question 13

Factor XIII

Answer 13

Fibrin stabilizing - cross links fibrin.
synthesized in liver.
NOT vit K dep.