Coagulation drugs Flashcards
drugs used to reduce clotting
platelet aggregation inhibitors; anticoagulants; thrombolytics
drugs used in bleeding disorders
plasminogen activation inhibitors; protamine sulfate; vitamin k; serine protease inhibitors; plasma fractions
platelet aggregation inhibitors
dec synth/chemical signals for platelet aggregation; aspirin/other cox inhibitors; ADP receptor blockers; phosphodiesterase inhibitors; GP IIb/IIIA receptor blockers on platelets
aspirin characteristics
prototype cox inhibitor -> inhibits thromboxane A2 synth
ADP receptor blockers
1st gen - ticlopidine; 2nd gen - clopidogrel; 3rd gen - prasugrel
ticlopidine, clopidogrel, prasugrel pk
prodrugs; slow onset; loading dose may be req’d
ticlopidine, clopidogrel, prasugrel pd
irreversible inhibitor of P2Y12 (ADP receptor on platelet surface)
ticlopidine, clopidogrel, prasugrel uses
pt’s intolerant to aspirin; combo w/aspirin; prevention
phosphodiesterase inhibitors - dipyridamole pd
inhibit phosphodiesterase -> inc cAMP; block adenosine uptake (acts at A2 receptors - activate platelet adenylyl cyclase)
dipyridamole uses
combo w/aspirin/warfarin - preventative (prosthetic heart valves); test coronary reserve; NOT anti-anginal (could provoke acute attack - coronary steal)
phosphodiesterase inhibitors - cilostazol characteristics
newer; promotes vasodilation, inhibition of platelet aggregation; treat intermittent claudication (window shopper disease)
blockers of GP IIb/IIIA receptors characteristics
for acute coronary syndromes
blockers of GP IIb/IIIA receptors
ABCIXIMAB; eptifibatide; tirofiban
ABCIXIMAB characteristics
monoclonal antibody against human GP IIb/IIIa
eptifibatide characteristics
cyclic peptide reversible antagonist of GP IIb/IIIa
tirofiban characteristics
nonpeptide reversible antagonist of GP IIb/IIIa
anticoagulants
unfractioned heparin (UFH) -> lead to low molecular weight heparins (LMWH) -> lead to selective factor Xa inhibitors; direct thrombin inhibitors (DTIs); coumarin anticoagulants