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Hematology II Coagulation Disorders > Coagulation Disorders > Flashcards

Coagulation Disorders Flashcards

1
Q

Intrinsic Pathway Factor Activation

A 
Collagen, Platelet Factor III (PF3)
Factor XII -> Factor XI -> Factor IX -> IXa
Thrombin + Factor VIII -> VIIIa
Factor VIIIa + IXa -> Factor X -> Xa
Begining of Common Pathway
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2
Q

Extrinsic Pathway Factor Activation

A 
TF (thromboplastin), calcium, Platelet Factor III (PF3)
Trauma + Factor VII -> VIIa
Trauma + TF -> TF
VIIa + TF -. Factor X-> Xa
Beginning of Common Pathway
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3
Q

Common Pathway Factor Activation

A 
X-> Xa
Thrombin + Factor V -> Va
Va + Xa + Prothrombin -> Thrombin
Thrombin + Fibrinogen -> Fibrin
Fibrin + XIIIa + thrombin = Stable Fibrin Clot
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4
Q

Normal Platelte Range

A

150 to 400 x10^9 / uL

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5
Q

Prothrombin Time (PT) measure which factors and monitors which therapy?

A

Extrinsic Pathway
I, II, V, VII, X
Warfarin

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6
Q

Partial Thromboplastin (PTT)Time measures which factors and monitors which therapy?

A

Intrinsic Pathway

XII, XI, IX, X, V, I

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7
Q

Described thrombin time (TT)

A

coagulation test that measures the interval to clot formation after the addition of thrombin to plasma. Often used to screen for the presence of heparin.

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8
Q

INR Calculation

A

(Patients PT/MNPT)ISI

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9
Q

Idiopathic Thrombocytopenic Purpura (ITP)

A 
Accelerated platelet destruction. 
Disorder of children
Bruising, petichae, mucosal bleeding
Occurs after upper respiratory/gastrointestinal infection
Spontaneous recover after 1-3 weeks
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10
Q

Thrombotic Thrombocytopenic Purpura (TTP)

A

Characterized by microangiopathic hemolytic anemia, throbocytopenia, neurological abnormalities
Women (30-40yrs) more than men
Diarrhea, anorexia, weakness, fatigue
Acute, recurrent, drug induced, chronic

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11
Q

Hemolytic Uremic Syndrom (HUS)

A 
Similar to TTP
Children 
Shigella dysenteriae or E.coli
Bloody diarrhea and erosive colon damage
Inhibition of platelet aggregation
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12
Q

Glanzmann’s Thrombasthenia

A

Autosomal recessive
Abnormal adhesion, defects in primary aggregation
Abnomality of platelet membrane GP IIb/IIIa complex
Manifests neonatal
Epistaxis and gingival bleeding, petechia, purpura,

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13
Q

von Willebrand’s Disease

A

Abnormalities of von Willebrand factor
Decreased adhesion of platelets to injured vessels
Impaired primary hemostasis
Autosomal dominant

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14
Q

Bernard-Soulier syndrome

A

Giant platelets
Prolonged bleeding time, thrombocytopenia, decreased platelet survival
Abnormal/missing glycoprotein Ib/IX/V

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15
Q

Hemophilia A

A

Factor 8 Deficiency
Sex linked recessive
Bleeds in deep muscle, joint hemorrhages, hemayomas, oozing

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16
Q

Hemophilia B

A

Factor IX Deficiency (Christmas Disease)

Same symptoms as Hemophilia A

17
Q

Hemophilia C

A

Factor XI Deficiency (Rosenthal syndrom)
Mild to moderate bleeding
Autosomal dominant
Ashkenazi Jews

18
Q 
Factor I (fibrinogen) Deficiency (Afribrinogenemia)
PT/PTT/CT
A

P/P/P

Fibrinogen is found in the COMMON pathway

19
Q 
Factor II (prothrombin) Deficiency
PT/PTT/CT
A

P/P/N

Prothrombin is found in the COMMON pathway

20
Q 
Factor V (labile factor) Deficiency (Owren's Disease)
PT/PTT/CT
A 
P/P/N
Factor V (labile factor) is found in the COMMON pathway
21
Q 
Factor VII (stable factor) Deficiency (Alexanders Disease)
PT/PTT/CT
A 
P/N/N
Factor VII (stable factor) is found in the EXTRINSIC pathway
22
Q

Factor VIII:C (antihemophilic factor) Deficiency (Hemophilia A)
PT/PTT/CT

A 
N/P/N
Factor VIII (antihemophilic factor) is found in the INTRINSIC pathway
23
Q

Factor VIII:vWF Deficiency (von Willebrand’s Disease)

PT/PTT/CT

A

N/N or P

VIII:vWF is found in the INTRINSIC pathway

24
Q 
Factor IX (christmas factor) Deficiency (Hemophilia B/Christmas Disease)
PT/PTT/CT`
A 
N/P/N
Factor IX (christmas factor) is found in the INTRINSIC pathway
25
Q 
Factor X (stuart prower) Deficiency 
PT/PTT/CT
A 
P/P/N
Factor X (stuart prower factor) is found in the COMMON pathway
26
Q

Factor XI Deficiency (Hemophilia C/Rosenthal Syndrom)

PT/PTT/CT

A 
N/P/N
Factor XI (plasma thromboplastin atecedent) is found in the INTRINSIC pathway
27
Q 
Factor XII (hageman factor) Deficiency 
PT/PTT/CT
A 
N/P/N
Factor XII (hageman factor) is found in the INSTRINSIC pathway
28
Q

Factor XIII (fibrin stabilizing factor) Deficiency

A

N/N/N

Clotting Disorder- fibrin clot will break down

29
Q

Define thrombocytopenia

A

Platelet conut below 150X10^9

30
Q

Disseminated Intravascular Coagulation

A

Uncontrolled activation of thrombin and consumption of coagulation factors
Shock, mucocutaneous bleeding
Sever thrombocytopenia

Hematology II Coagulation Disorders (2 decks)

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