Coagulation Cascade Pathways Flashcards
The Extrinsic Pathway is also known as
Tissue Factor Pathway
The Intrinsic Pathway is also known as
Contact Activation Pathway
The Tissue Factor Pathway is activated quickly and may be completed in as little as how many seconds?
15 Seconds
Tissue Thromboplastin (Factor III) is released by what?
Damaged Cells
When Factor III is released during the Tissue Factor Pathway, what Factor is activated?
Factor VII
When Factor VII is activated during the Tissue Factor Pathway, what Factor is activated next?
Factor X
Which Factor is required for all Coagulation Cascade Pathways?
Factor IV (Calcium)
What is required for all Coagulation Pathways in addition to Calcium?
Specific Phospholipids
What triggers the Contact
Activation Pathway?
Factors XI and XII coming into contact with the surface of the damaged blood vessel endothelium
What Factors are activated in the Contact Activation Pathway after Factors XI and XII come into contact with the surface of the damaged blood vessel endothelium?
Factors VIII and IX
After the Factor VIII and IX complex is activated in the Contact
Activation Pathway, what is needed to activate factor X?
The Presence of Platelet Factor 3
What is activated by both extrinsic and intrinsic Coagulation Cascade Pathways?
Factor X
Once activated, Factor X forms a complex with what cofactor?
Factor V
The Common Pathway converts Prothrombin (II) to what?
Thrombin
During the Common Pathway, Thrombin splits peptides from fibrinogen (I) to produce what?
Fibrin Clot (XIII)
