Coagulation Cascade/Factors Flashcards
Factor IA
Fibrin
Factor I
Fibrinogen
Factor II
Prothrombin
Factor IIA
Thrombin
Factor III
Tissue Factor
Factor IV
Calcium
Factor V
Proaccelerin
Factor VI
(Not assigned)
Factor VII
Proconvertin
Factor VIII
Anti-hemophiliac factor
Factor IX
Christmas
Factor X
Stuart-Prower
Factor XI
Plasma
Factor XII
Hageman
Factor XIII
Fibrin stabilizing factor
What is NAP an acronym for?
Nitric oxide
ADP
PGI2
What is coagulation (by definition)
The process by which soluble fibrinogen is converted into insoluble fibrin
(From I to IA)
_____ ________ cells do not tolerate ______ ___________ _______ near them
HEALTHY ENDOTHELIAL cells do not tolerate ACTIVATED COAGULATION FACTORS near them
Healthy endothelial tissue is…
Anti thrombic & anti coagulant
The endothelial lining is a…
Biological active tissue
PT vs PTT
PT is the time for plasma to clot, PTT is for blood to clot
What is an INtrinsic pathway?
Blood clotting on its own without outside factors
What is an EXtrinsic pathway
A factor besides the blood has initiated coagulation
Which pathway, intrinsic or extrinsic, is fastest?
Extrinsic is fastest
What factor initiates coagulation via extrinsic pathways?
Factor 7 (proconvertin)
What factor initiates coagulation via intrinsic pathways?
Factor XII (Hageman)
How big are platelets?
2-3 um
How long do platelets live?
8-10 days
